Table 1 Summary of the simulation protocol comprising main parameter values, marker and survival time distributions used for each of the simulation scenarios
Scenario | β0 | β1 | β2 | bi | Σ11 | Σ22 | Σ33 | h0(t) |
|---|---|---|---|---|---|---|---|---|
a) LOCF and measurement error impact | ||||||||
1 | 3.2 | 0 | 0 | N(0,Σ11) | 0 | 0 | 0 | Weibull (0.1,1.4) |
2 | 3.2 | −0.07 | 0 | N2(0,Σ) | 1.44 | 0.04 | 0 | Weibull (0.1,1.4) |
b1) Marker distribution | ||||||||
3 | 3.2 | −0.07 | 0 | BM ∗ | 1.44 | 0 | 0 | Weibull (0.1,1.4) |
4 | 3.2 | −0.07 | 0 | χ2(0.72) | 1.44 | 0 | 0 | Weibull (0.1,1.4) |
5 | 3.2 | −0.07 | 0 | Γ(0.5,1.7) | 1.44 | 0 | 0 | Weibull (0.1,1.4) |
6 | 3.2 | −0.07 | 0 | N(0,Σ11) | 1.44 | 0 | 0 | Weibull (0.1,1.4) |
b2) Marker profile | ||||||||
7 | 3.2 | −0.07 | 0.004 | N3(0,Σ) | 1.44 | 0.6 | 0.09 | Weibull (0.1,1.4) |
8 | 3.2 | −0.16 | 0.01 | N3(0,Σ) | 1.44 | 0.6 | 0.09 | Weibull (0.1,1.4) |
b3) Baseline hazard | ||||||||
9 | 3.2 | −0.07 | 0 | N2(0,1.44) | 1.44 | 0.04 | 0 | h0(t)nonm |