Table 1 SiVETs and non-SiVETs cohorts’ participant eligibility criteria

Inclusion

• At least 3 and no more than 18 months of follow up in the OBC₁ or OBC₂

• HIV-1 negative and willing to undergo HIV testing

• Aged ≥18 years and ≤ 49 years

• Able and willing to provide written informed consent

• Able and willing to provide adequate locator information including physical address

• Willing and able to return for follow-up clinic visits

• Intending to reside in study area for at least one year

Females only

• Willing to undergo pregnancy testing

• Not breastfeeding and no intent for pregnancy in the next one year

• Willing to use effective contraception during the study and at least 3 months after the last vaccination

Inclusion

• At least 3 months and no more than 18 months of follow up in OBC₁ or OBC₂

• Still in follow up in the OBCs

• HIV-1 negative and willing to undergo HIV testing

Exclusion

Exclusion

• HIV positive

• History of severe allergic reaction to any substance

• An acute or chronic illness

• Contraindication for Hepatitis B vaccine

• Participation in another clinical trial

• Hepatitis B exposure, as assessed by surface antigen (HBsAg) and core antibody (HBcAb) titers (only SiVET₂)

• Not willing to provide written consent

HIV positive