Skip to main content

Table 2 List of outcome categories/outcomes in COS from the included studies by study type

From: A scoping review of core outcome sets and their ‘mapping’ onto real-world data using prostate cancer as a case study

Outcome classification/OutcomesAll COS studies (n = 11);COS for clinical trials or clinical research (n = 8)COS for practice (n = 2)COS/patient reported outcomes (n = 1)
No. ONo. SNo. ONo. SNo. ONo. SNo. ONo. S
Mortality and survival18815632NANA
 Survival2 2 0 NA 
 Overall survival5 3 2 NA 
 Cause- (or disease) specific survival6 5 1 NA 
 Relative survival1 1 0 NA 
 Metastasis-free survival2 2 0 NA 
 Progression-free survival1 1 0 NA 
 Biochemical recurrence-free survival1 1 0 NA 
Outcomes relating to neoplasms1971861100
  (Change in) prostate-specific antigen (PSA) levels3 3 0 0 
 Measurable disease response1 1 0 0 
 Time to progression2 2 0 0 
 Disease progression/Progression rate2 2 0 0 
 Progression-free probability1 1 0 0 
 Development of metastases1 1 0 0 
 Metastases-free probability1 1 0 0 
 Symptomatic skeletal event1 0 1 0 
 Local disease1 1 0 0 
 Positive surgical margins1 1 0 0 
 Response duration1 1 0 0 
 Failure-free probability1 1 0 0 
 Development of castration-resistant disease1 1 0 0 
 Treatment failure2 2 0 0 
Renal and urinary outcomes136833221
 Urinary incontinence4 2 1 1 
 Urinary obstruction/irritation3 1 1 1 
 Urinary symptoms1 0 1 0 
 Voiding behaviour1 1 0 0 
 Haematuria1 1 0 0 
 Pelvic pain1 1 0 0 
 Lymphedema1 1 0 0 
 Urinary functioning1 1 0 0 
Gastrointestinal outcomes65322211
 Bowel symptoms3 0 2 1 
 Faecal incontinence1 1 0 0 
 Bowel functioning1 1 0 0 
 Diarrhoea1 1 0 0 
Endocrine outcomes33002211
 Hormonal symptoms3 0 2 1 
Reproductive system outcomes66332211
 Erectile/sexual function2 2 0 0 
 Erectile/sexual dysfunction (impotence)3 1 1 1 
 Sexual symptoms1 0 1 0 
General outcomes83313121
 Pain2 0 1 1 
 Fatigue2 0 1 1 
 Bone pain1 1 0 0 
 Weight loss1 1 0 0 
 Anaemia1 1 0 0 
 Performance status1 0 1 0 
Physical functioning33111111
 Physical wellbeing/functioning3 1 1 1 
Emotional functioning/wellbeing44221111
 Mental/emotional wellbeing/functioning4 2 1 1 
Social functioning11110000
 Social functioning1 1 0 0 
Role functioning11110000
 Role functioning1 1 0 0 
Global quality of life66660000
 Quality of life6 6 0 0 
Economic outcomes22220000
 Cost-effectiveness1 1 0 0 
 Costs1 1 0 0 
Need for intervention42212100
 Need for salvage therapy1 1 0 0 
 Need for curative treatment1 1 0 0 
 Need for pain medication1 0 1 0 
 Procedures need for local progression1 0 1 0 
Delivery of care11110000
 Time to treatment failure1 1 0 0 
Adverse events/effects86642200
 Adverse events3 2 1 0 
 Perioperative deaths1 1 0 0 
 Thromboembolic disease1 1 0 0 
 Bothersome or symptomatic urethral or anastomotic stricture1 1 0 0 
 Side-effects of hormonal therapy1 1 0 0 
 Major systemic therapy effects1 0 1 0 
Total103 72 22 9 
  1. NA Not applicable,