Table 1 Risk of seizure recurrence by treatment – arm A
From: Modelling seizure rates rather than time to an event within clinical trials of antiepileptic drugs
Variable | Hazard Ratio (95% CI) | Negative binomial: rate of seizures | |||
|---|---|---|---|---|---|
PWP-TT: Rate of recurrent seizures | Cox: First seizure | Cox: 12-month remission | |||
Treatment | Carbamazepine | 1.00 | 1.00 | 1.00 | 1.00 |
Gabapentin | 0.97 (0.89, 1.07) | 1.34 (1.13, 1.59) | 0.76 (0.63, 0.91) | 1.45 (1.06, 1.99) | |
Lamotrigine | 0.98 (0.89, 1.08) | 1.23 (1.04, 1.45) | 0.91 (0.76, 1.09) | 0.91 (0.67, 1.25) | |
Oxcarbazepine | 0.91 (0.82, 1.02) | 1.03 (0.84, 1.26) | 1.03 (0.83, 1.28) | 0.67 (0.46, 0.98) | |
Topiramate | 1.06 (0.97, 1.17) | 1.06 (0.90, 1.26) | 0.84 (0.70, 1.01) | 1.25 (0.91, 1.72) | |
Intercept | N/A | N/A | N/A | −2.68 (−2.89, − 2.45) | |