Table 5 Risk of seizure recurrence by treatment - sensitivity analyses (arm A)
From: Modelling seizure rates rather than time to an event within clinical trials of antiepileptic drugs
Hazard Ratio (95% CI) | ||||||
|---|---|---|---|---|---|---|
Variable | On randomised drug only | Recurrent tonic-clonic recurrent seizures only | On randomised drug only & recurrent tonic-clonic seizures only | Recurrent tonic-clonic & complex partial seizures only | On randomised drug only & recurrent tonic-clonic & complex partial seizures only | |
Treatment | Carbamazepine | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Gabapentin | 1.19 (1.05, 1.36) | 1.01 (0.87, 1.17) | 1.02 (0.85, 1.23) | 1.01 (0.87, 1.17) | 1.02 (0.85, 1.23) | |
Lamotrigine | 0.94 (0.83, 1.07) | 0.97 (0.84, 1.13) | 0.83 (0.69, 0.99) | 0.97 (0.84, 1.13) | 0.83 (0.69, 0.99) | |
Oxcarbazepine | 0.83 (0.71, 0.97) | 0.87 (0.71, 1.05) | 0.75 (0.59, 0.96) | 0.87 (0.71, 1.05) | 0.75 (0.59, 0.96) | |
Topiramate | 1.18 (1.03, 1.34) | 1.02 (0.87, 1.19) | 0.99 (0.83, 1.19) | 1.02 (0.87, 1.19) | 0.99 (0.83, 1.19) | |