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Table 1 Main demographic, clinical and biochemical data of LN patients with hypothyroidism and euthyroidism

From: Application of principal component analysis and logistic regression model in lupus nephritis patients with clinical hypothyroidism

 Euthyroid(n = 95)Hypothyroidism(n = 48)P-value
Female, n(%)79 (83.2)42 (87.5)0.497
Mean age (years)33.1 ± 12.935.6 ± 12.00.660
SBP (mmHg)128.9 ± 22.7136.1 ± 22.50.568
DBP (mmHg)83.3 ± 16.886.9 ± 14.80.899
Disease duration (months)36 (6–108)15 (3–69)0.212
Fever, n (%)9 (9.5)2 (4.2)0.335
Rash, n (%)39 (41.1)47 (97.9)0.016
Photosensitivity, n (%)17 (17.9)23 (47.9)0.617
Raynaud’s phenome, n (%)11 (11.6)5 (10.4)0.835
Alopecia, n (%)25 (26.3)20 (41.7)0.062
Oral ulcers, n (%)11 (11.6)3 (6.3)0.475
Arthritis, n (%)34 (35.8)22 (45.8)0.245
SLEDAI10.5 ± 4.812.3 ± 4.40.330
WBC(109/L)6.3 (4.4–8.7)5.1 (3.6–8.3)0.124
Hb (g/L)107 (91–126)95 (75–105)0.001
PLT(109/L)198.3 ± 94.4144.5 ± 74.50.096
TP (g/L)58.1 ± 10.550.2 ± 11.80.381
ALB (g/L)29.5 ± 7.021.9 ± 6.80.957
GLB (g/L)28.6 ± 6.928.3 ± 8.80.070
Scr (umol/L)72 (62–107)116 (81.6–208.9)0.000
BUN (mmol/L)5.2 (3.9–8.2)10.7 (5.9–15.4)0.000
UA (umol/L)362.2 (294.6–463.1)436.6 (342.7–568.2)0.006
TG (mg/dl)1.8 (1.3–3.0)2.6 (1.8–4.0)0.001
TC (mmol/L)5.2 (4.2–6.4)5.7 (4.7–7.7)0.099
HDL (mmol/L)1.3 (0.9–1.7)1.2 (1.0–1.5)0.215
LDL (mmol/L)3.2 (2.4–4.0)4.1 (3.0–5.1)0.016
HDL/TC0.3 ± 0.10.2 ± 0.10.299
ESR (mm/h)36 (26–55)34.5 (21.5–58.5)0.457
CRP (mg/L)4.8 (2.3–9.8)4.9 (1.9–10.3)0.661
C3(mg/L)460 (361–674)327.5 (328.5–440)0.000
C4(mg/L)109 (59.5–153)62.1 (42.1–126.8)0.049
IgG (g/L)12.6 (8.7–19.0)12.4 (7.4–20.1)0.942
IgA (g/L)2.4 (1.5–3.2)2.5 (1.7–3.4)0.489
IgM (g/L)1.0 (1.0–1.5)0.8 (0.5–1.4)0.248
Anti-dsDNA antibodies,
n (%)
57 (60.0)35 (72.9)0.185
Anti-Sm antibodies, n (%)27 (28.4)13 (27.1)0.715
Anti-SSA antibodies, n (%)52 (54.7)34 (70.8)0.133
Anti-SSB antibodies, n (%)13 (13.7)6 (0.1)0.292
Anti-U1RNP antibodies, n (%)44 (46.3)24 (50)0.902
Anti-RNP antibodies, n (%)34 (35.8)21 (43.8)0.260
  1. Datas are given as mean (SD), median, and interquartile range or as number and percentage. Significant differences between two groups are indicated in bold. SBP systolic blood pressure, DBP diastolic blood pressure, WBC white blood cell, Hb haemoglobin, PLT platelet count, TP total protein, ALB albumin, GLB globulin, SCr serum creatinine, BUN blood urea nitrogen, UA blood uric acid, TG triglyceride, TC cholesterol, LDL low-density lipoprotein, HDL high-density lipoprotein, ESR erythrocyte sedimentation rate, CRP C-reactive protein, Anti-dsDNA antibodies anti-double-stranded DNA antibodies, Anti-Sm antibodies Anti-Smith antibodies, Anti-U1RNP antibodies anti-U1 ribonucleoprotein antibodies, Anti-RNP antibodies Anti-ribosomal P protein antibodies, SLEDAI systemic lupus erythematosus disease activity