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Table 1 Main demographic, clinical and biochemical data of LN patients with hypothyroidism and euthyroidism

From: Application of principal component analysis and logistic regression model in lupus nephritis patients with clinical hypothyroidism

 

Euthyroid(n = 95)

Hypothyroidism(n = 48)

P-value

Female, n(%)

79 (83.2)

42 (87.5)

0.497

Mean age (years)

33.1 ± 12.9

35.6 ± 12.0

0.660

SBP (mmHg)

128.9 ± 22.7

136.1 ± 22.5

0.568

DBP (mmHg)

83.3 ± 16.8

86.9 ± 14.8

0.899

Disease duration (months)

36 (6–108)

15 (3–69)

0.212

Fever, n (%)

9 (9.5)

2 (4.2)

0.335

Rash, n (%)

39 (41.1)

47 (97.9)

0.016

Photosensitivity, n (%)

17 (17.9)

23 (47.9)

0.617

Raynaud’s phenome, n (%)

11 (11.6)

5 (10.4)

0.835

Alopecia, n (%)

25 (26.3)

20 (41.7)

0.062

Oral ulcers, n (%)

11 (11.6)

3 (6.3)

0.475

Arthritis, n (%)

34 (35.8)

22 (45.8)

0.245

SLEDAI

10.5 ± 4.8

12.3 ± 4.4

0.330

WBC(109/L)

6.3 (4.4–8.7)

5.1 (3.6–8.3)

0.124

Hb (g/L)

107 (91–126)

95 (75–105)

0.001

PLT(109/L)

198.3 ± 94.4

144.5 ± 74.5

0.096

TP (g/L)

58.1 ± 10.5

50.2 ± 11.8

0.381

ALB (g/L)

29.5 ± 7.0

21.9 ± 6.8

0.957

GLB (g/L)

28.6 ± 6.9

28.3 ± 8.8

0.070

Scr (umol/L)

72 (62–107)

116 (81.6–208.9)

0.000

BUN (mmol/L)

5.2 (3.9–8.2)

10.7 (5.9–15.4)

0.000

UA (umol/L)

362.2 (294.6–463.1)

436.6 (342.7–568.2)

0.006

TG (mg/dl)

1.8 (1.3–3.0)

2.6 (1.8–4.0)

0.001

TC (mmol/L)

5.2 (4.2–6.4)

5.7 (4.7–7.7)

0.099

HDL (mmol/L)

1.3 (0.9–1.7)

1.2 (1.0–1.5)

0.215

LDL (mmol/L)

3.2 (2.4–4.0)

4.1 (3.0–5.1)

0.016

HDL/TC

0.3 ± 0.1

0.2 ± 0.1

0.299

ESR (mm/h)

36 (26–55)

34.5 (21.5–58.5)

0.457

CRP (mg/L)

4.8 (2.3–9.8)

4.9 (1.9–10.3)

0.661

C3(mg/L)

460 (361–674)

327.5 (328.5–440)

0.000

C4(mg/L)

109 (59.5–153)

62.1 (42.1–126.8)

0.049

IgG (g/L)

12.6 (8.7–19.0)

12.4 (7.4–20.1)

0.942

IgA (g/L)

2.4 (1.5–3.2)

2.5 (1.7–3.4)

0.489

IgM (g/L)

1.0 (1.0–1.5)

0.8 (0.5–1.4)

0.248

Anti-dsDNA antibodies,

n (%)

57 (60.0)

35 (72.9)

0.185

Anti-Sm antibodies, n (%)

27 (28.4)

13 (27.1)

0.715

Anti-SSA antibodies, n (%)

52 (54.7)

34 (70.8)

0.133

Anti-SSB antibodies, n (%)

13 (13.7)

6 (0.1)

0.292

Anti-U1RNP antibodies, n (%)

44 (46.3)

24 (50)

0.902

Anti-RNP antibodies, n (%)

34 (35.8)

21 (43.8)

0.260

  1. Datas are given as mean (SD), median, and interquartile range or as number and percentage. Significant differences between two groups are indicated in bold. SBP systolic blood pressure, DBP diastolic blood pressure, WBC white blood cell, Hb haemoglobin, PLT platelet count, TP total protein, ALB albumin, GLB globulin, SCr serum creatinine, BUN blood urea nitrogen, UA blood uric acid, TG triglyceride, TC cholesterol, LDL low-density lipoprotein, HDL high-density lipoprotein, ESR erythrocyte sedimentation rate, CRP C-reactive protein, Anti-dsDNA antibodies anti-double-stranded DNA antibodies, Anti-Sm antibodies Anti-Smith antibodies, Anti-U1RNP antibodies anti-U1 ribonucleoprotein antibodies, Anti-RNP antibodies Anti-ribosomal P protein antibodies, SLEDAI systemic lupus erythematosus disease activity
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BMC Medical Research Methodology

ISSN: 1471-2288

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