From: Optimal, minimax and admissible two-stage design for phase II oncology clinical trials
p0 | p1 | α | β | αT | 1-βT | n1 | a1 | r1 | PETF1 | n | r | ENF | Type | q |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.05 | 0.25 | 0.05 | 0.20 | 0.047 | 0.812 | 9 | 0 | 3 | 0.639 | 17 | 3 | 11.9 | Optimal | [0.000, 0.655] |
0.043 | 0.801 | 12 | 0 | 3 | 0.560 | 16 | 3 | 13.8 | Minimax | [0.655, 1.000] | ||||
0.10 | 0.30 | 0.05 | 0.20 | 0.047 | 0.805 | 10 | 1 | 5 | 0.738 | 29 | 6 | 15.0 | Optimal | [0.000, 0.200] |
0.048 | 0.812 | 11 | 1 | 4 | 0.716 | 27 | 6 | 15.5 | Admissible | [0.200, 0.474] | ||||
0.049 | 0.817 | 12 | 1 | 4 | 0.685 | 26 | 6 | 16.4 | Admissible | [0.474, 0.661] | ||||
0.043 | 0.802 | 19 | 2 | 5 | 0.741 | 24 | 6 | 20.3 | Minimax | [0.661, 1.000] | ||||
0.30 | 0.50 | 0.05 | 0.20 | 0.046 | 0.803 | 18 | 6 | 11 | 0.728 | 42 | 18 | 24.5 | Optimal | [0.000, 0.250] |
0.049 | 0.807 | 19 | 6 | 11 | 0.676 | 39 | 17 | 25.5 | Admissible | [0.250, 0.634] | ||||
0.049 | 0.800 | 27 | 8 | 14 | 0.592 | 36 | 16 | 30.7 | Minimax | [0.634, 1.000] | ||||
0.049 | 0.800 | 21 | 0 | 12 | 0.009 | 36 | 16 | 35.9 | Inadmissible | – | ||||
0.05 | 0.25 | 0.10 | 0.10 | 0.093 | 0.903 | 9 | 0 | 3 | 0.639 | 24 | 3 | 14.4 | Optimal | [0.000, 0.130] |
0.083 | 0.905 | 10 | 0 | 3 | 0.610 | 22 | 3 | 14.7 | Admissible | [0.130, 0.333] | ||||
0.078 | 0.905 | 11 | 0 | 3 | 0.584 | 21 | 3 | 15.2 | Admissible | [0.333, 0.500] | ||||
0.074 | 0.903 | 13 | 0 | 3 | 0.538 | 20 | 3 | 16.2 | Minimax | [0.500, 1.000] | ||||
0.10 | 0.30 | 0.10 | 0.10 | 0.085 | 0.900 | 13 | 1 | 4 | 0.656 | 31 | 6 | 19.2 | Optimal | [0.000, 0.123] |
0.099 | 0.904 | 18 | 2 | 5 | 0.762 | 26 | 5 | 19.9 | Admissible | [0.123, 0.231] | ||||
0.095 | 0.903 | 16 | 1 | 5 | 0.532 | 25 | 5 | 20.2 | Minimax | [0.231, 1.000] | ||||
0.30 | 0.50 | 0.10 | 0.10 | 0.097 | 0.901 | 20 | 6 | 10 | 0.656 | 47 | 19 | 29.3 | Optimal | [0.000, 0.048] |
0.091 | 0.900 | 20 | 6 | 11 | 0.625 | 45 | 18 | 29.4 | Admissible | [0.048, 0.117] | ||||
0.093 | 0.900 | 23 | 7 | 12 | 0.640 | 42 | 17 | 29.8 | Admissible | [0.117, 0.492] | ||||
0.097 | 0.901 | 26 | 7 | 13 | 0.486 | 39 | 16 | 32.7 | Minimax | [0.492, 1.000] | ||||
0.05 | 0.25 | 0.05 | 0.10 | 0.049 | 0.902 | 9 | 0 | 4 | 0.631 | 30 | 4 | 16.8 | Optimal | [0.000, 0.091] |
0.047 | 0.913 | 10 | 0 | 4 | 0.600 | 29 | 4 | 17.6 | Inadmissible | – | ||||
0.047 | 0.907 | 10 | 0 | 3 | 0.610 | 28 | 4 | 17.0 | Inadmissible | – | ||||
0.046 | 0.911 | 11 | 0 | 3 | 0.584 | 27 | 4 | 17.7 | Inadmissible | – | ||||
0.042 | 0.901 | 11 | 0 | 3 | 0.584 | 26 | 4 | 17.2 | Admissible | [0.091, 0.565] | ||||
0.045 | 0.903 | 13 | 0 | 3 | 0.538 | 25 | 4 | 18.5 | Minimax | [0.565, 1.000] | ||||
0.10 | 0.30 | 0.05 | 0.10 | 0.048 | 0.901 | 17 | 2 | 5 | 0.784 | 41 | 8 | 22.2 | Optimal | [0.000, 0.032] |
0.048 | 0.902 | 18 | 2 | 6 | 0.740 | 35 | 7 | 22.4 | Admissible | [0.032, 0.444] | ||||
0.047 | 0.900 | 16 | 1 | 5 | 0.532 | 33 | 7 | 24.0 | Minimax | [0.444, 1.000] | ||||
0.30 | 0.50 | 0.05 | 0.10 | 0.047 | 0.900 | 25 | 8 | 14 | 0.683 | 56 | 23 | 34.8 | Optimal | [0.000, 0.250] |
0.049 | 0.901 | 26 | 8 | 14 | 0.637 | 53 | 22 | 35.8 | Admissible | [0.250, 0.670] | ||||
0.049 | 0.900 | 37 | 11 | 18 | 0.579 | 50 | 21 | 42.5 | Minimax | [0.670, 1.000] | ||||
0.05 | 0.900 | 28 | 0 | 15 | 0.008 | 50 | 21 | 49.8 | Inadmissible | – |