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Table 5 Factorial stratification analysis and confounder-controlling stratification analysis

From: Advanced stratification analyses in molecular association meta-analysis: methodology and application

A.

Exposure

Stratum 1

Stratum 2

ICR and ORint

Reference

OR2−

\( {\displaystyle \begin{array}{c} ICR={OR}_{2+}-{OR}_{1+}-{OR}_{2-}+1\\ {}{OR}_{int}={OR}_{2+}/\left({OR}_{1+}\times {OR}_{2-}\right)\end{array}} \)

+

OR1+

OR2+

B.

Exposure

Stratum 1

Stratum 2

Combined OR

Reference1

Reference2

\( {OR}_{IV}=\frac{W_{IV1}{OR}_1+{W}_{IV2}{OR}_2}{W_{IV1}+{W}_{IV2}} \)

+

OR1

OR2

  1. Note: OR odds ratio, ICR interaction contrast ratio