Advanced stratification analyses in molecular association meta-analysis: methodology and application

Table 6 Standard stratification analysis by NSAID use status for the association between the PPARγ rs1801282 polymorphism and the risk of cancer

PPARγ rs1801282	Non-NSAID users		NSAID users		Test of association and heterogeneity (b)
PPARγ rs1801282	Case	Control	Case	Control	Test of association and heterogeneity (b)
CC	2208	2773	1059	1653	0.743 (0.673–0.820) ~ 46.70%
CG + GG	664	902	338	575	0.811 (0.622–1.056) ~ 51.8%
Test of association and heterogeneity (a)	0.932 (0.830–1.046) ~ 0.00%		0.942 (0.724–1.226) ~ 58.70%		0.765 (0.576–1.015) ~ 68.30%

Number of included studies: 6
Variation across strata: \( {P}_{\left({\upchi}^2\right)a}=0.942 \); \( {P}_{\left({\upchi}^2\right)b}=0.543 \)
Adjusted ORs across stratification: OR_(combined)a(95 % CI) = 0.934 (0.840 − 1.038); OR_(combined)b(95 % CI) = 0.751 (0.685 − 0.824)
Crude ORs: OR_a(95 % CI) = 0.927 (0.845 − 1.017); OR_b(95 % CI) = 0.799 (0.840 − 1.038)

ISSN: 1471-2288