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Table 7 Standard stratification analysis by smoking status for the association between the MDM2 rs2279744 polymorphism and the risk of lung cancer

From: Advanced stratification analyses in molecular association meta-analysis: methodology and application

MDM2 rs2279744

Non-smokers

Smokers

Test of association and heterogeneity (b)

Case

Control

Case

Control

TT

273

861

1393

1208

2.274 (1.015–5.094) ~ 95.50%

TG + GG

711

1057

2363

2253

1.796 (0.735–4.387) ~ 98.30%

Test of association and heterogeneity (a)

1.334 (1.125–1.581) ~ 40.50%

1.072 (0.823–1.394) ~ 83.20%

2.469 (1.116–5.461) ~ 95.90%

  1. Number of included studies: 5
  2. Variation across strata: \( {P}_{\left({\upchi}^2\right)a}=0.160 \); \( {P}_{\left({\upchi}^2\right)b}=0.701 \)
  3. Adjusted OR across stratification: OR(combined)a(95 % CI) = 1.232 (1.054 − 1.410); OR(combined)b(95 % CI) = 2.045 (1.124 − 3.722)
  4. Crude ORs: ORa(95 % CI) = 1.110 (0.871 − 1.414); ORb(95 % CI) = 1.908 (0.793 − 4.589)
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BMC Medical Research Methodology

ISSN: 1471-2288

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