From: Comparison of hierarchical EMAX and NDLM models in dose-response for early phase clinical trials
Large monotonic effect | d = 1 Control | d = 2 2.60 | d = 3 4.17 | d = 4 5.40 | d = 5 5.92 | d = 6 6.20 | d = 7 7.76 | d = 8 9.52 |
---|---|---|---|---|---|---|---|---|
pMAX | ||||||||
Hierarchical | 0.00 | 0.00 | 0.00 | 0.16 | 0.00 | 0.18 | 0.25 | 0.41 |
simple NDLM | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.26 | 0.30 | 0.39 |
2nd order NDLM | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.96 |
Pr(Pd > Pl) | ||||||||
Hierarchical | 0.00 | 0.38 | 0.40 | 1.00 | 0.42 | 1.00 | 1.00 | 1.00 |
simple NDLM | 0.00 | 0.41 | 0.55 | 0.98 | 0.57 | 1.00 | 1.00 | 1.00 |
2nd order NDLM | 0.00 | 0.85 | 0.94 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Pr(phaseIII success) | ||||||||
Hierarchical | 0.03 | 0.22 | 0.24 | 1.00 | 0.25 | 0.99 | 0.99 | 1.00 |
simple NDLM | 0.03 | 0.21 | 0.34 | 0.93 | 0.38 | 1.00 | 1.00 | 1.00 |
2nd order NDLM | 0.03 | 0.61 | 0.80 | 0.95 | 0.98 | 1.00 | 1.00 | 1.00 |