Table 3 Simulation results for evaluating a predictive biomarker in the setting of the E1900 trial
From: Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies
Biomarker | Link for | Relative Efficiency | Relative Cost-Efficiency | ||||||
|---|---|---|---|---|---|---|---|---|---|
Interaction | RS-2 | RS-3 | GT-2 | GT-3 | RS-2 | RS-3 | GT-2 | GT-3 | |
FLD3-ITD | logit | 0.54 | 0.34 | 0.86 | 0.70 | 1.08 | 1.01 | 1.72 | 2.10 |
log | 0.50 | 0.30 | 0.86 | 0.71 | 0.99 | 0.89 | 1.72 | 2.13 | |
identity | 0.53 | 0.34 | 0.86 | 0.70 | 1.06 | 1.01 | 1.72 | 2.11 | |
DNMT3A | logit | 0.56 | 0.35 | 0.88 | 0.75 | 1.13 | 1.05 | 1.75 | 2.25 |
log | 0.52 | 0.32 | 0.86 | 0.73 | 1.04 | 0.97 | 1.72 | 2.19 | |
identity | 0.54 | 0.35 | 0.87 | 0.74 | 1.08 | 1.03 | 1.74 | 2.22 | |