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Table 3 Simulation results for evaluating a predictive biomarker in the setting of the E1900 trial

From: Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies

Biomarker Link for Relative Efficiency Relative Cost-Efficiency
Interaction RS-2 RS-3 GT-2 GT-3 RS-2 RS-3 GT-2 GT-3
FLD3-ITD logit 0.54 0.34 0.86 0.70 1.08 1.01 1.72 2.10
log 0.50 0.30 0.86 0.71 0.99 0.89 1.72 2.13
identity 0.53 0.34 0.86 0.70 1.06 1.01 1.72 2.11
DNMT3A logit 0.56 0.35 0.88 0.75 1.13 1.05 1.75 2.25
log 0.52 0.32 0.86 0.73 1.04 0.97 1.72 2.19
identity 0.54 0.35 0.87 0.74 1.08 1.03 1.74 2.22