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Table 2 Hazard ratios associated with the Charlson Comorbidity Index according to different assessment methods

From: Impact of comorbidity assessment methods to predict non-cancer mortality risk in cancer patients: a retrospective observational study using the National Health Insurance Service claims-based data in Korea

Ascertainment period

CCI

Non-cancer death

Either inpatient or outpatient claims

Inpatient claim only

Outpatient claim only

Washout window

Lookback

HR

95% CI

HR

95% CI

HR

95% CI

No WP

1-year

1–2

1.9

(1.4, 2.6)

2.0

(1.5, 2.7)

1.5

(1.1, 2.0)

 

3–4

3.1

(2.1, 4.6)

3.4

(2.3, 5.1)

2.2

(1.4, 3.4)

 

≥5

6.1

(3.9, 9.4)

7.9

(4.9, 12.7)

3.8

(2.0, 7.1)

2-year

1–2

1.6

(1.2, 2.3)

1.7

(1.3, 2.4)

1.4

(1.0, 1.8)

 

3–4

2.6

(1.7, 3.9)

3.8

(2.6, 5.5)

1.6

(1.0, 2.5)

 

≥5

5.6

(3.6, 8.6)

7.9

(5.0, 12.5)

4.2

(2.5, 7.1)

3-year

1–2

1.5

(1.1, 2.2)

1.8

(1.3, 2.4)

1.3

(0.9, 1.7)

 

3–4

2.7

(1.8, 4.0)

3.6

(2.5, 5.3)

1.8

(1.2, 2.7)

 

≥5

4.9

(3.3, 7.6)

8.0

(5.1, 12.5)

3.7

(2.3, 5.9)

30-day

1-year

1–2

1.6

(1.2, 2.2)

2.7

(1.8, 4.0)

1.5

(1.1, 1.9)

 

3–4

2.2

(1.4, 3.5)

5.0

(2.7, 9.3)

1.7

(1.0, 2.9)

 

≥5

6.1

(3.5, 10.5)

7.1

(3.6, 14.0)

5.2

(2.7, 10.0)

2-year

1–2

1.3

(1.0, 1.7)

2.2

(1.5, 3.2)

1.2

(0.9, 1.6)

 

3–4

1.7

(1.1, 2.6)

4.9

(2.9, 8.2)

1.2

(0.7, 2.0)

 

≥5

5.5

(3.3, 9.1)

7.5

(3.9, 14.3)

5.2

(3.0, 8.9)

3-year

1–2

1.2

(0.9, 1.6)

2.2

(1.5, 3.2)

1.2

(0.9, 1.5)

 

3–4

1.8

(1.2, 2.7)

4.4

(2.7, 7.1)

1.5

(0.9, 2.2)

 

≥5

3.6

(2.3, 5.7)

6.7

(3.5, 12.7)

3.7

(2.3, 6.1)

90-day

1-year

1–2

1.5

(1.1, 1.9)

3.0

(1.9, 4.7)

1.3

(0.9, 1.7)

 

3–4

1.7

(1.0, 2.8)

4.4

(2.1, 9.0)

1.4

(0.8, 2.4)

 

≥5

6.4

(3.5, 11.6)

7.5

(3.8, 14.9)

5.9

(2.6, 13.6)

2-year

1–2

1.1

(0.8, 1.4)

2.2

(1.5, 3.3)

1.0

(0.7, 1.3)

 

3–4

1.3

(0.8, 2.1)

4.5

(2.6, 7.8)

1.0

(0.6, 1.6)

 

≥5

5.5

(3.3, 9.1)

7.8

(4.1, 15.1)

4.9

(2.7, 8.7)

3-year

1–2

1.0

(0.8, 1.4)

2.2

(1.5, 3.2)

1.0

(0.7, 1.3)

 

3–4

1.4

(0.9, 2.2)

4.0

(2.4, 6.7)

1.1

(0.7, 1.8)

 

≥5

3.8

(2.4, 5.9)

6.9

(3.6, 13.3)

3.7

(2.2, 6.3)

  1. No WP Washout window period was not used, CCI Charlson Comorbidity Index, HR Hazard ratio, CI Confidence interval
  2. a) Prognostic prediction models were based on a sex-adjusted Cox proportional hazards model accounting for left truncated and right-censored data