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Table 2 Hazard ratios associated with the Charlson Comorbidity Index according to different assessment methods

From: Impact of comorbidity assessment methods to predict non-cancer mortality risk in cancer patients: a retrospective observational study using the National Health Insurance Service claims-based data in Korea

Ascertainment period CCI Non-cancer death
Either inpatient or outpatient claims Inpatient claim only Outpatient claim only
Washout window Lookback HR 95% CI HR 95% CI HR 95% CI
No WP 1-year 1–2 1.9 (1.4, 2.6) 2.0 (1.5, 2.7) 1.5 (1.1, 2.0)
  3–4 3.1 (2.1, 4.6) 3.4 (2.3, 5.1) 2.2 (1.4, 3.4)
  ≥5 6.1 (3.9, 9.4) 7.9 (4.9, 12.7) 3.8 (2.0, 7.1)
2-year 1–2 1.6 (1.2, 2.3) 1.7 (1.3, 2.4) 1.4 (1.0, 1.8)
  3–4 2.6 (1.7, 3.9) 3.8 (2.6, 5.5) 1.6 (1.0, 2.5)
  ≥5 5.6 (3.6, 8.6) 7.9 (5.0, 12.5) 4.2 (2.5, 7.1)
3-year 1–2 1.5 (1.1, 2.2) 1.8 (1.3, 2.4) 1.3 (0.9, 1.7)
  3–4 2.7 (1.8, 4.0) 3.6 (2.5, 5.3) 1.8 (1.2, 2.7)
  ≥5 4.9 (3.3, 7.6) 8.0 (5.1, 12.5) 3.7 (2.3, 5.9)
30-day 1-year 1–2 1.6 (1.2, 2.2) 2.7 (1.8, 4.0) 1.5 (1.1, 1.9)
  3–4 2.2 (1.4, 3.5) 5.0 (2.7, 9.3) 1.7 (1.0, 2.9)
  ≥5 6.1 (3.5, 10.5) 7.1 (3.6, 14.0) 5.2 (2.7, 10.0)
2-year 1–2 1.3 (1.0, 1.7) 2.2 (1.5, 3.2) 1.2 (0.9, 1.6)
  3–4 1.7 (1.1, 2.6) 4.9 (2.9, 8.2) 1.2 (0.7, 2.0)
  ≥5 5.5 (3.3, 9.1) 7.5 (3.9, 14.3) 5.2 (3.0, 8.9)
3-year 1–2 1.2 (0.9, 1.6) 2.2 (1.5, 3.2) 1.2 (0.9, 1.5)
  3–4 1.8 (1.2, 2.7) 4.4 (2.7, 7.1) 1.5 (0.9, 2.2)
  ≥5 3.6 (2.3, 5.7) 6.7 (3.5, 12.7) 3.7 (2.3, 6.1)
90-day 1-year 1–2 1.5 (1.1, 1.9) 3.0 (1.9, 4.7) 1.3 (0.9, 1.7)
  3–4 1.7 (1.0, 2.8) 4.4 (2.1, 9.0) 1.4 (0.8, 2.4)
  ≥5 6.4 (3.5, 11.6) 7.5 (3.8, 14.9) 5.9 (2.6, 13.6)
2-year 1–2 1.1 (0.8, 1.4) 2.2 (1.5, 3.3) 1.0 (0.7, 1.3)
  3–4 1.3 (0.8, 2.1) 4.5 (2.6, 7.8) 1.0 (0.6, 1.6)
  ≥5 5.5 (3.3, 9.1) 7.8 (4.1, 15.1) 4.9 (2.7, 8.7)
3-year 1–2 1.0 (0.8, 1.4) 2.2 (1.5, 3.2) 1.0 (0.7, 1.3)
  3–4 1.4 (0.9, 2.2) 4.0 (2.4, 6.7) 1.1 (0.7, 1.8)
  ≥5 3.8 (2.4, 5.9) 6.9 (3.6, 13.3) 3.7 (2.2, 6.3)
  1. No WP Washout window period was not used, CCI Charlson Comorbidity Index, HR Hazard ratio, CI Confidence interval
  2. a) Prognostic prediction models were based on a sex-adjusted Cox proportional hazards model accounting for left truncated and right-censored data