Table 4 Comparison of performance of the HRnV models (based on 5-fold cross-validation), HEART, TIMI, and GRACE scores in predicting 30-day major adverse cardiac events (MACE). The cut-off values were defined as the points nearest to the upper-left corner on the ROC curves
| Â | AUC (95% CI) | Cut-off | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) |
|---|---|---|---|---|---|---|
Stepwise | 0.887 (0.859–0.916) | 0.3140 | 79.4 (74.3–84.4) | 78.8 (75.4–82.3) | 62.8 (57.5–68.2) | 89.4 (86.7–92.2) |
PCA | 0.899 (0.872–0.926) | 0.2881 | 85.4 (81.0–89.8) | 78.5 (75.0–81.9) | 64.1 (59.0–69.3) | 92.3 (89.9–94.7) |
KPCA | 0.896 (0.869–0.923) | 0.3489 | 81.8 (77.0–86.6) | 82.1 (78.9–85.3) | 67.3 (62.0–72.6) | 90.9 (88.4–93.4) |
LSA | 0.899 (0.872–0.926) | 0.2884 | 85.4 (81.0–89.8) | 78.6 (75.2–82.1) | 64.3 (59.1–69.5) | 92.3 (89.9–94.7) |
GRP | 0.896 (0.868–0.923) | 0.2965 | 85.0 (80.6–89.5) | 78.5 (75.0–81.9) | 64.0 (58.8–69.2) | 92.1 (89.6–94.5) |
SRP | 0.898 (0.871–0.925) | 0.2940 | 84.6 (80.1–89.1) | 79.6 (76.2–82.9) | 65.1 (59.9–70.3) | 92.0 (89.5–94.4) |
MDS | 0.901 (0.874–0.928) | 0.3095 | 83.4 (78.8–88.0) | 81.6 (78.3–84.8) | 67.1 (61.8–72.4) | 91.6 (89.1–94.1) |
Isomap | 0.888 (0.860–0.917) | 0.3468 | 78.5 (73.4–83.7) | 82.7 (79.5–85.8) | 67.1 (61.7–72.5) | 89.5 (86.9–92.2) |
LLE | 0.898 (0.870–0.925) | 0.3140 | 85.0 (80.6–89.5) | 79.4 (76.0–82.8) | 65.0 (59.8–70.2) | 92.2 (89.7–94.6) |
HEART | 0.841 (0.808–0.874) | 5 | 78.9 (73.9–84.0) | 72.8 (69.1–76.5) | 56.7 (51.4–61.9) | 88.5 (85.5–91.4) |
TIMI | 0.681 (0.639–0.723) | 2 | 63.6 (57.6–69.6) | 58.4 (54.3–62.5) | 40.8 (35.9–45.7) | 78.0 (74.0–82.1) |
GRACE | 0.665 (0.623–0.707) | 107 | 64.0 (58.0–70.0) | 60.8 (56.7–64.9) | 42.4 (37.3–47.4) | 78.9 (75.0–82.8) |