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Table 3 Input parameters considered in the simulation according to the setting

From: Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

 

\(p_{1}^{(0)},p_{2}^{(0)}\)

HR1,HR2

ρ

β1,β2

Copula

Scenarios

 

0.05

0.1

0.3

0.5

0.6

0.8

0.9

0.1

0.3

0.5

0.5

1

2

Frank

 

Setting 1

x

x

x

x

x

x

x

x

x

x

 

x

 

x

396

Setting 2

x

x

x

x

x

x

x

x

x

x

x

x

x

x

3,168

  1. Lows the total number of simulated scenarios. Scenarios with observed proportions \(p_{1}^{(0)}=p_{2}^{(0)}=0.5\) in both settings as well as scenarios with exponential distribution in both components in Setting 2 are not considered
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BMC Medical Research Methodology

ISSN: 1471-2288

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