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Table 3 Input parameters considered in the simulation according to the setting

From: Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

  \(p_{1}^{(0)},p_{2}^{(0)}\) HR1,HR2 ρ β1,β2 Copula Scenarios
  0.05 0.1 0.3 0.5 0.6 0.8 0.9 0.1 0.3 0.5 0.5 1 2 Frank  
Setting 1 x x x x x x x x x x   x   x 396
Setting 2 x x x x x x x x x x x x x x 3,168
  1. Lows the total number of simulated scenarios. Scenarios with observed proportions \(p_{1}^{(0)}=p_{2}^{(0)}=0.5\) in both settings as well as scenarios with exponential distribution in both components in Setting 2 are not considered
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BMC Medical Research Methodology

ISSN: 1471-2288

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