|Objective||Desired feature(s) of a randomization procedure|
|Mitigate potential for selection bias||A procedure should have high degree of randomness.|
|Mitigate potential for chronological bias.||A procedure should balance treatment assignments over time.|
|Valid and efficient treatment comparison||
A procedure should have established statistical properties, provide strong control of false positive rate and yield unbiased, low variance estimates of the treatment difference.|
A procedure should preserve the unconditional allocation ratio (e.g. 1:1) at every allocation step and achieve approximately or exactly the target sample sizes per group.
|Ease of implementation||Validated statistical software for implementing a randomization procedure must be in place.|