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Table 1 Details of primary (mortality) outcome for meta-analyses

From: Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Meta_analysis Reference Study Second_outcome Third_outcome Year No. RCTs mortality Total patients Total events I^2 Mortality sse graphics Mortality sse test
Griesdale [34] Bivariate Hypoglcaemia   2009 26 13,572 3362 52.25 ok 0.610
Annane [35] Bivariate Shock reversal   2009 20 2384 840 52.48 ok 0.090
Bangalore [36] Trivariate Non-fatal MI Non-fatal stroke 2008 23 11,862 304 9.23 ok 0.720
Marik [37] Trivariate Infection Hospital LOS 2008 13 2553 689 57.30 ok 0.990
Marik [37] Trivariate Hospital LOS Infection 2008 4 144 27 63.99 ok 0.090
Marik [37] Trivariate Hospital LOS Infection 2008 7 300 26 0.00 ok 0.750
Chan [38] Trivariate VAP MV length 2007 11 3242 553 37.03 ok 0.010
Gonzalez [39] Bivariate Rebleeding   2008 18 1304 198 0.00 ok 0.470
Ho [40] Trivariate Pneumonia ICULOS 2006 8 517 125 0.00 ok 0.430
Ho [41] Bivariate ICU LOS   2008 14 1184 299 0.00 ok 0.460
Siempos [42] Bivariate VAP   2010 11 2014 514 0.00 ok 0.990
Singh [43] Bivariate Pneumonia   2009 11 7514 582 1.05 ok 0.040
Peterson [44] Bivariate Neurological outcome   2008 8 781 208 28.16 ok 0.250
Silvestri [45] Bivariate infection   2007 31 4747 1003 3.23 ok 0.990
Whitlock [46] Trivariate New Atrial fibrillation Bleed post-operative 2008 16 2038 65 0.00 ok 0.190
Piccini [47] Trivariate CVS death Cardiomyopathy 2009 15 8522 715 0.00 ok 0.150
Landoni [48] Bivariate MI   2010 27 3350 659 11.93 ok 0.160
Brar [49] Trivariate MI TVR 2009 13 7352 288 0.00 ok 0.170
Landoni [50] Trivariate Acute kidney injury Hospital LOS 2007 11 1118 191 0.00 ok 0.635
Mazaki [51] Bivariate Infection   2008 15 1832 65 0.00 ok 0.250
Masip [52] Bivariate Intubation   2005 9 468 78 0.00 ok 0.870
Oldani [53] Trivariate Infection Hospital LOS 2015 24 2834 797 22.22 query 0.020
Szakmany [54] Trivariate VAP MV length 2015 14 2406 747 0.00 ok 0.360
Alkhawaja [55] Trivariate Pneumonia ICU LOS 2015 11 977 219 0.00 ok 0.970
Van Zanten [56] Trivariate Infection Hospital LOS 2015 10 1022 163 0.00 ok 0.240
Wan [57] Bivariate Hospital LOS MV length 2015 9 706 188 0.00 ok 0.380
Teo [58] Bivariate Clinical response   2014 13 905 96 0.00 ok 0.320
Manzanares [59] Trivariate Infection MV length 2012 21 2485 631 22.75 ok 0.960
Tian [60] Trivariate Pneumonia Hospital LOS 2018 16 3225 1110 57.20 query 0.043
Rhodes [61] Bivariate Cinical cure   2018 17 3220 534 0.00 ok 0.060
Nunez-Patino [62] Trivariate Neurological outcome ICU LOS 2018 10 1361 308 0.00 ok 0.680
Kawano-Dourado [63] Bivariate RRT   2018 10 3665 336 0.00 ok 0.960
Dallimore [64] Bivariate ICU LOS   2018 13 1781 473 27.74 ok 0.340
Chong [65] Bivariate Myocardial infarction   2018 27 10,740 1148 12.66 ok 0.440
Yang [66] Trivariate Renal function recovery RRT time 2017 9 1636 682 62.70 ok 0.020
Osadnik [67] Trivariate Hospital LOS MV 2017 12 854 119 0.00 ok 0.667
Lu [68] Trivariate ICU LOS MV length 2017 16 1179 297 7.35 ok 0.260
Chen [69] Trivariate ICU LOS RRT 2017 17 2754 198 6.16 ok 0.150
Qureshi [70] Bivariate Acute kidney injury   2016 29 14,167 3321 31.86 ok 0.950
Elke [71] Trivariate Infection Hospital LOS 2016 16 3167 1004 0.00 ok 0.540
Parikh [72] Trivariate Hospital LOS ICU LOS 2016 16 3473 913 5.31 ok 0.990
Davies [73] Trivariate VAP Hospital LOS 2017 14 3238 711 19.75 ok 0.880
Abroug [74] Bivariate Clinical response   2014 9 1097 79 0.00 ok 0.340
Manzanares [75] Bivariate infection   2016 17 1638 340 0.00 ok 0.740
Peter [76] Trivariate Mechanical ventilation Hospital LOS 2002 15 793 138 0.00 ok 0.195
Wang [77] Trivariate Rebleeding Surgery 2010 6 1052 21 0.00 ok 0.950
Tao [78] Trivariate Infection MV length 2016 10 780 208 0.00 ok 0.840
Tang [79] Trivariate Antibiotic exposure ICU LOS 2009 7 1458 131 0.00 ok 0.410
Muscedere [80] Trivariate VAP MV length 2011 6 1682 341 0.00 ok 0.580
  1. LOS Length of stay (days), ICU Intensive care unit, VAP Ventilator associated pneumonia, CVS Cardiovascular, MV Mechanical ventilation, TVR Target vessel revascularization, RRT Renal replacement therapy, MI Myocardial infarction, Ok Visual assessment of contour-enhanced revealed no problematic asymmetry, query Visual assessment of contour-enhanced revealed problematic asymmetry, sse Small study effects