Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Moran, John L.

doi:10.1186/s12874-021-01336-4

BMC Medical Research Methodology

Table 1 Details of primary (mortality) outcome for meta-analyses

From: Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Meta_analysis	Reference	Study	Second_outcome	Third_outcome	Year	No. RCTs mortality	Total patients	Total events	I^2	Mortality sse graphics	Mortality sse test
Griesdale	[34]	Bivariate	Hypoglcaemia		2009	26	13,572	3362	52.25	ok	0.610
Annane	[35]	Bivariate	Shock reversal		2009	20	2384	840	52.48	ok	0.090
Bangalore	[36]	Trivariate	Non-fatal MI	Non-fatal stroke	2008	23	11,862	304	9.23	ok	0.720
Marik	[37]	Trivariate	Infection	Hospital LOS	2008	13	2553	689	57.30	ok	0.990
Marik	[37]	Trivariate	Hospital LOS	Infection	2008	4	144	27	63.99	ok	0.090
Marik	[37]	Trivariate	Hospital LOS	Infection	2008	7	300	26	0.00	ok	0.750
Chan	[38]	Trivariate	VAP	MV length	2007	11	3242	553	37.03	ok	0.010
Gonzalez	[39]	Bivariate	Rebleeding		2008	18	1304	198	0.00	ok	0.470
Ho	[40]	Trivariate	Pneumonia	ICULOS	2006	8	517	125	0.00	ok	0.430
Ho	[41]	Bivariate	ICU LOS		2008	14	1184	299	0.00	ok	0.460
Siempos	[42]	Bivariate	VAP		2010	11	2014	514	0.00	ok	0.990
Singh	[43]	Bivariate	Pneumonia		2009	11	7514	582	1.05	ok	0.040
Peterson	[44]	Bivariate	Neurological outcome		2008	8	781	208	28.16	ok	0.250
Silvestri	[45]	Bivariate	infection		2007	31	4747	1003	3.23	ok	0.990
Whitlock	[46]	Trivariate	New Atrial fibrillation	Bleed post-operative	2008	16	2038	65	0.00	ok	0.190
Piccini	[47]	Trivariate	CVS death	Cardiomyopathy	2009	15	8522	715	0.00	ok	0.150
Landoni	[48]	Bivariate	MI		2010	27	3350	659	11.93	ok	0.160
Brar	[49]	Trivariate	MI	TVR	2009	13	7352	288	0.00	ok	0.170
Landoni	[50]	Trivariate	Acute kidney injury	Hospital LOS	2007	11	1118	191	0.00	ok	0.635
Mazaki	[51]	Bivariate	Infection		2008	15	1832	65	0.00	ok	0.250
Masip	[52]	Bivariate	Intubation		2005	9	468	78	0.00	ok	0.870
Oldani	[53]	Trivariate	Infection	Hospital LOS	2015	24	2834	797	22.22	query	0.020
Szakmany	[54]	Trivariate	VAP	MV length	2015	14	2406	747	0.00	ok	0.360
Alkhawaja	[55]	Trivariate	Pneumonia	ICU LOS	2015	11	977	219	0.00	ok	0.970
Van Zanten	[56]	Trivariate	Infection	Hospital LOS	2015	10	1022	163	0.00	ok	0.240
Wan	[57]	Bivariate	Hospital LOS	MV length	2015	9	706	188	0.00	ok	0.380
Teo	[58]	Bivariate	Clinical response		2014	13	905	96	0.00	ok	0.320
Manzanares	[59]	Trivariate	Infection	MV length	2012	21	2485	631	22.75	ok	0.960
Tian	[60]	Trivariate	Pneumonia	Hospital LOS	2018	16	3225	1110	57.20	query	0.043
Rhodes	[61]	Bivariate	Cinical cure		2018	17	3220	534	0.00	ok	0.060
Nunez-Patino	[62]	Trivariate	Neurological outcome	ICU LOS	2018	10	1361	308	0.00	ok	0.680
Kawano-Dourado	[63]	Bivariate	RRT		2018	10	3665	336	0.00	ok	0.960
Dallimore	[64]	Bivariate	ICU LOS		2018	13	1781	473	27.74	ok	0.340
Chong	[65]	Bivariate	Myocardial infarction		2018	27	10,740	1148	12.66	ok	0.440
Yang	[66]	Trivariate	Renal function recovery	RRT time	2017	9	1636	682	62.70	ok	0.020
Osadnik	[67]	Trivariate	Hospital LOS	MV	2017	12	854	119	0.00	ok	0.667
Lu	[68]	Trivariate	ICU LOS	MV length	2017	16	1179	297	7.35	ok	0.260
Chen	[69]	Trivariate	ICU LOS	RRT	2017	17	2754	198	6.16	ok	0.150
Qureshi	[70]	Bivariate	Acute kidney injury		2016	29	14,167	3321	31.86	ok	0.950
Elke	[71]	Trivariate	Infection	Hospital LOS	2016	16	3167	1004	0.00	ok	0.540
Parikh	[72]	Trivariate	Hospital LOS	ICU LOS	2016	16	3473	913	5.31	ok	0.990
Davies	[73]	Trivariate	VAP	Hospital LOS	2017	14	3238	711	19.75	ok	0.880
Abroug	[74]	Bivariate	Clinical response		2014	9	1097	79	0.00	ok	0.340
Manzanares	[75]	Bivariate	infection		2016	17	1638	340	0.00	ok	0.740
Peter	[76]	Trivariate	Mechanical ventilation	Hospital LOS	2002	15	793	138	0.00	ok	0.195
Wang	[77]	Trivariate	Rebleeding	Surgery	2010	6	1052	21	0.00	ok	0.950
Tao	[78]	Trivariate	Infection	MV length	2016	10	780	208	0.00	ok	0.840
Tang	[79]	Trivariate	Antibiotic exposure	ICU LOS	2009	7	1458	131	0.00	ok	0.410
Muscedere	[80]	Trivariate	VAP	MV length	2011	6	1682	341	0.00	ok	0.580

LOS Length of stay (days), ICU Intensive care unit, VAP Ventilator associated pneumonia, CVS Cardiovascular, MV Mechanical ventilation, TVR Target vessel revascularization, RRT Renal replacement therapy, MI Myocardial infarction, Ok Visual assessment of contour-enhanced revealed no problematic asymmetry, query Visual assessment of contour-enhanced revealed problematic asymmetry, sse Small study effects

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