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Table 2 Matrix table of annualised relapse rate ratios (95% credible intervals) for network meta-analysis (NMA) using hierarchical models including randomised controlled trials and real-world evidencea

From: Methods for the inclusion of real-world evidence in network meta-analysis

  1. For the hierarchical NMA of RCTs (lower triangle), ARRRs are reported as rows vs columns (i.e., Natalizumab vs placebo ARRR 0.35 (0.14, 0.74). For the hierarchical NMA of RCTs and RWEs (upper triangle), ARRRs are reported as columns vs rows (i.e., Natalizumab vs placebo ARRR 0.40 (0.26, 0.70)
  2. a Lower triangle consists of results from NMA of randomised controlled trials (RCTs) only and upper triangle consists of results from hierarchical NMA of RCTs and real-world evidence (RWE)