From: An adaptive gBOIN design with shrinkage boundaries for phase I dose-finding trials
 |  | Selection percentage |  | Allocation | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | d1 | d2 | d3 | d4 | d5 | d6 |  | d1 | d2 | d3 | d4 | d5 | d6 |
Scenario 1 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.93 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | Â | 11.9 | 2.4 | 0.5 | 0.1 | 0.0 | 0.0 | |
gBOINS | 0.93 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | Â | 12.0 | 2.4 | 0.5 | 0.1 | 0.0 | 0.0 | |
Scenario 2 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.03 | 0.91 | 0.06 | 0.00 | 0.00 | 0.00 | Â | 7.4 | 42.6 | 8.2 | 1.4 | 0.3 | 0.1 | |
gBOINS | 0.02 | 0.92 | 0.06 | 0.00 | 0.00 | 0.00 | Â | 11.6 | 37.5 | 8.8 | 1.6 | 0.4 | 0.1 | |
Scenario 3 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.12 | 0.76 | 0.12 | 0.01 | 0.00 | Â | 1.6 | 13.5 | 32.3 | 9.9 | 2.2 | 0.5 | |
gBOINS | 0.00 | 0.09 | 0.78 | 0.12 | 0.01 | 0.00 | Â | 1.6 | 15.4 | 30.2 | 9.7 | 2.4 | 0.6 | |
Scenario 4 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.00 | 0.23 | 0.60 | 0.16 | 0.02 | Â | 1.1 | 3.0 | 17.5 | 25.6 | 9.8 | 3.0 | |
gBOINS | 0.00 | 0.00 | 0.20 | 0.62 | 0.16 | 0.02 | Â | 1.1 | 3.3 | 18.6 | 24.3 | 9.6 | 3.1 | |
Scenario 5 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.00 | 0.00 | 0.30 | 0.50 | 0.19 | Â | 1.0 | 1.6 | 5.0 | 19.5 | 21.1 | 11.9 | |
gBOINS | 0.00 | 0.00 | 0.00 | 0.28 | 0.53 | 0.19 | Â | 1.0 | 1.6 | 5.6 | 19.4 | 21.0 | 11.4 | |
Scenario 6 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.00 | 0.00 | 0.03 | 0.35 | 0.61 | Â | 1.0 | 1.2 | 2.4 | 7.7 | 19.6 | 28.0 | |
g BOINS | 0.00 | 0.00 | 0.00 | 0.02 | 0.34 | 0.64 | Â | 1.0 | 1.2 | 2.4 | 7.7 | 20.1 | 27.6 | |
Scenario 7 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.06 | 0.84 | 0.10 | 0.00 | 0.00 | Â | 1.6 | 16.6 | 64.0 | 14.7 | 2.6 | 0.6 | |
gBOINS | 0.00 | 0.04 | 0.89 | 0.07 | 0.00 | 0.00 | Â | 1.6 | 20.3 | 61.7 | 14.5 | 1.6 | 0.3 | |
Scenario 8 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.00 | 0.17 | 0.69 | 0.13 | 0.01 | Â | 1.1 | 2.9 | 25.2 | 50.9 | 16.1 | 3.8 | |
gBOINS | 0.00 | 0.00 | 0.12 | 0.75 | 0.13 | 0.01 | Â | 1.1 | 3.2 | 26.7 | 51.2 | 15.6 | 3.1 | |
Scenario 9 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.00 | 0.00 | 0.26 | 0.57 | 0.18 | Â | 1.0 | 1.6 | 5.0 | 30.1 | 42.6 | 19.7 | |
gBOINS | 0.00 | 0.00 | 0.00 | 0.20 | 0.66 | 0.14 | Â | 1.0 | 1.6 | 5.4 | 30.4 | 43.4 | 18.1 | |
Scenario 10 | 0.10 | 0.15 | 0.20 | 0.25 | 0.30 | 0.35 | Â | Â | Â | Â | Â | Â | Â | |
gBOIN | 0.00 | 0.00 | 0.00 | 0.01 | 0.33 | 0.66 | Â | 1.0 | 1.2 | 2.5 | 8.6 | 32.7 | 54.1 | |
gBOINS | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.73 | Â | 1.0 | 1.2 | 2.5 | 8.7 | 34.1 | 52.5 |