Table 3 Comparison of methods
Method | Missing data | Imputation of missing data |
|---|---|---|
MI-RD | Off-treatment visits are used | Yes using MI |
MMRM | Off-treatment visits are set to missing | No |
RTB | Off-treatment Week 26 values are set to missing. | Yes using MI |
J2R | Off-treatment visits are set to missing | Yes using MI |
Trimmed means | Off-treatment Week 26 values are set to missing. | No |
Mehrotra’s control-based | Off-treatment Week 26 values are set to missing. | No |