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Table 1 Description of the simulated scenarios when K = 2

From: Enrichment Bayesian design for randomized clinical trials using categorical biomarkers and a binary outcome

Scenarios Subset B Subset A Theoretical Values
Outcomes p1B p0B p1A p0A θA θB/θA RR
Scenario 1 0.40 0.40 0.30 0.30 1.000 1.000 1.000
Scenario 2 0.40 0.40 0.30 0.40 0.750 1.330 0.875
Scenario 3 0.40 0.40 0.20 0.37 0.540 1.850 0.779
Scenario 4 0.40 0.40 0.20 0.50 0.400 2.500 0.647
  1. Here, pjk denotes the probability of death in the arm j in the subset k, and θk denotes the relative risk of death in the experimental versus the control arm in subset k. RR refers to the overall treatment effect.