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Table 1 Dose escalation and de-escalation boundaries (TTL = 0.3)

From: Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial

Design Action Num of patients treated at current dose
3 6 9 12 15 18
mTPI Escalate if Num of DLTs \(\le\) 0 1 1 2 2 3
De-escalate if Num of DLTs \(\ge\) 2 3 4 5 7 8
Keyboard Escalate if Num of DLTs \(\le\) 0 1 2 2 3 4
De-escalate if Num of DLTs \(\ge\) 2 3 4 5 6 7
BOIN Escalate if Num of DLTs \(\le\) 0 1 2 2 3 4
De-escalate if Num of DLTs \(\ge\) 2 3 4 5 6 7