Table 1 Dose escalation and de-escalation boundaries (TTL = 0.3)
From: Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial
Design | Action | Num of patients treated at current dose | |||||
|---|---|---|---|---|---|---|---|
3 | 6 | 9 | 12 | 15 | 18 | ||
mTPI | Escalate if Num of DLTs \(\le\) | 0 | 1 | 1 | 2 | 2 | 3 |
De-escalate if Num of DLTs \(\ge\) | 2 | 3 | 4 | 5 | 7 | 8 | |
Keyboard | Escalate if Num of DLTs \(\le\) | 0 | 1 | 2 | 2 | 3 | 4 |
De-escalate if Num of DLTs \(\ge\) | 2 | 3 | 4 | 5 | 6 | 7 | |
BOIN | Escalate if Num of DLTs \(\le\) | 0 | 1 | 2 | 2 | 3 | 4 |
De-escalate if Num of DLTs \(\ge\) | 2 | 3 | 4 | 5 | 6 | 7 | |