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Table 1 Causal effects estimated from 200 simulated datasets for each configuration from two MR methods (Bayesian, IVW) when β1=β2=0.3, using four metrics: mean, standard deviation (sd), coverage and power. The six configurations were generated from three missing rates of the exposures (80%, 50%, 20%) and two levels of IV strength (α=0.3 and 0.1). \(\hat {\beta }_{1}\): estimated causal effect of X1 on \(Y_{1}, \hat {\beta }_{2}\): estimated causal effect of X2 on Y2

From: Bayesian mendelian randomization with study heterogeneity and data partitioning for large studies

Missing rate

α

\(\widehat {\beta _{1}}\)

\(\widehat {\beta _{2}}\)

  

Bayesian

IVW

Bayesian

IVW

  

mean

sd

coverage

power

mean

sd

coverage

power

mean

sd

coverage

power

mean

sd

coverage

power

80%

0.3

0.299

0.005

0.980

1

0.217

0.101

0.790

0.685

0.298

0.005

0.970

1

0.209

0.086

0.765

0.665

 

0.1

0.298

0.015

0.975

1

0.081

0.141

0.695

0.065

0.299

0.015

0.985

1

0.071

0.146

0.690

0.045

50%

0.3

0.300

0.004

0.975

1

0.245

0.118

0.920

0.580

0.299

0.004

0.980

1

0.265

0.113

0.935

0.595

 

0.1

0.302

0.013

0.960

1

0.169

0.277

0.925

0.115

0.302

0.013

0.955

1

0.122

0.268

0.900

0.075

20%

0.3

0.299

0.004

0.970

1

0.260

0.203

0.915

0.255

0.299

0.004

0.970

1

0.276

0.185

0.955

0.285

 

0.1

0.303

0.012

0.955

1

0.193

0.439

0.945

0.050

0.302

0.012

0.950

1

0.181

0.469

0.945

0.070