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Fig. 3 | BMC Medical Research Methodology

Fig. 3

From: A data-driven pipeline to extract potential adverse drug reactions through prescription, procedures and medical diagnoses analysis: application to a cohort study of 2,010 patients taking hydroxychloroquine with an 11-year follow-up

Fig. 3

Diagram of case-crossover. Schematic representation of a case–crossover analysis. The case-defining event is the prescription of a level 5 ATC class other than HCQ and the prescription is the HCQ drug. Three control periods are selected (shown as CTR) and one risk period (shown as RISK) for each individual. The duration of the periods (risk and control) is set to three months in this example. The washout period (shown as WO) has a standard duration of one month

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