Fig. 3

Stratified Adaptive Bryant & Day (SABD) design. e: ‹‹enrichment››. + : ‹‹inclusion of additional››. N₁⁻ and N₁⁺: number of patients to be included at the first stage. N₂⁻, N₂⁺ and N_2e⁺: number of patients to be included at the second stage. N⁻ = N₁⁻ + N₂⁻, N⁺ = N₁⁺ + N₂⁺ and N_e⁺ = N₁⁺ + N_2e⁺: total number of patients to be included. k_R1⁻, k_T1⁻, k_R1⁺ and k_T1⁺: first stage stopping boundaries. k_R⁻, k_T⁻, k_R⁺, k_T⁺, k_Re⁺ and k_Te⁺: second stage stopping boundaries. X_R1⁻, X_T1⁻, X_R1⁺ and X_T1⁺: number of responses and non-toxicities observed during the first stage. X_R2⁻, X_T2⁻ X_R2⁺, X_T2⁺, X_R2e⁺ and X_T2e⁺: number of responses and non-toxicities observed during the second stage. X_R⁻ = X_R1⁻ + X_R2⁻, X_T⁻ = X_T1⁻ + X_T2⁻, X_R⁺ = X_R1⁺ + X_R2⁺, X_T⁺ = X_T1⁺ + X_T2⁺, X_Re⁺ = X_R1⁺ + X_R2e⁺ and X_Te⁺ = X_T1⁺ + X_T2e⁺: total number of responses and non-toxicities observed