Table 1 Study design features and levels

Payment and support

Payment you will receive ^a

• $0

• $500

• $2,000*

Transport

• Free transport is provided*

• Prepaid card for travel

• Transport costs can be claimed back

Study Hours

• Study undertaken during normal office hours (9–5, Mon-Fri)

• Option to participate out of office hours*

Childcare

• Free childcare provided*

• No childcare provided

Concierge Service Provided

• Yes*

• No

Administration / Procedures

Does treatment or study require an injection or infusion?

• Yes

• No*

Does treatment or study require an invasive procedure?

• No*

• Minimally invasive procedure

• Invasive procedure

Treatment-related

Number of participants who will have a serious side effect

• 0 out of 10 (0%)*

• 2 out of 10 (20%)

• 9 out of 10 (90%)

Number of participants who will receive a placebo

• 0 out of 10 (0%, there is no placebo)*

• 3 out of 10 (30%)

• 5 out of 10 (50%)

Is it possible to continue on treatment after trial?

• Yes*

• No

Are you required to stop using your current medications?

• Yes

• No*

Study location and time commitment

Study duration

• 1 month*

• 1 year

• 2 years

Time commitment per month at home

• 2 h / month*

• 10 h / month

• 30 h / month

Time commitment per month away from home (i.e. time at study site and travel to site)

• 2 h / month*

• 10 h / month

• 30 h / month

Data collection and feedback

Does the study involve wearing a device?

• Yes

• No*

How will you provide self-reported data?

• Paper-based questionnaire

• Electronic device*

Will you be told the results of the study?

• No

• Yes, the average results of everyone who took part

• Yes, your own clinical results*