Fig. 4

HRQoL theoretical mean trajectories (in black) and mean of the HRQoL predicted mean trajectories over the simulations (in color) in the control arm (dashed lines) and the experimental arm (solid lines), i.e., representation of the functions given by, respectively, β₀ + β₁t + β₂{arm × t} and \(\overline{{\hat{\beta}}_0}+\overline{{\hat{\beta}}_1}t+\overline{{\hat{\beta}}_2}\left\{ arm\times t\right\}\), according to t with t the time in months and arm the treatment arm indicator. HRQoL, health-related quality of life; JM, joint model; LMM, linear mixed model