Table 1 Sampling model, transform function and example of clinical endpoints for different types of one-parameter exponential families
f(ψ(k, j)) | h(ψ(k, j)) | Example of clinical endpoint |
|---|---|---|
Normal(ψ(k, j), σ2 ) | ψ(k, j) | Percentage change in tumor size |
Bernoulli(ψ(k, j)) | logit(ψ(k, j)) | Tumor response rate |
Exponential(ψ(k, j)) | log(ψ(k, j)) | Progression free survival |
Poisson(ψ(k, j)) | log(ψ(k, j)) | Number of tumor-involved nodes |