Skip to main content

Table 1 General characteristics stratified by consent status, based on the information extractable from the EHR

From: Asking informed consent may lead to significant participation bias and suboptimal cardiovascular risk management in learning healthcare systems

Variable

Total

N = 5730

Consent

N = 2378

Non-consent

N = 1907

Non-response

N = 1445

Age, median (Q1-Q3)a

67 (54.0–77.0)

63 (51.0–73.0)

71 (59.0–80.0)

66 (54.0–77.0)

Sex (women), N(%)a

2828 (49.4)

1083/2378 (45.5)

1025/1907 (53.7)

720/1445 (49.8)

High education, N(%)b

579 (19.2)

357/1724 (20.7)

153/1001 (15.3)

69/284 (24.3)

Current Smoking, N(%)b

471 (11.9)

264/2289 (11.5)

167/1281 (13.0)

40/372 (10.8)

Specialist specific OPDa

 -Cardiology

2783 (48.6)

1173/2378 (49.3)

815/1907 (42.7)

795/1445 (55.0)

 -Diabetology

303 (5.3)

171/2378 (7.2)

60/1907 (3.1)

72/1445 (5.0)

 -Geriatrics

1779 (31.0)

479/2378 (20.1)

909/1907 (47.7)

391/1445 (27.1)

 -Nephrology

435 (7.6)

270/2378 (11.4)

74/1907 (3.9)

91/1445 (6.3)

 -Vascular medicine

430 (7.5)

285/2378 (12.0)

49/1907 (2.6)

96/1445 (6.6)

Physical Activity per week (METminutes), median(Q1-Q3)b

4480.0 (2265.0- 7710.0)

4800 (2550.0–7995.0)

3675 (1638.8–6840.0)

5490.0 (2955.0–8026.5)

Previous AMI, CABG, CHF, Stroke, ICH, TIA, PAD (IC, AAA, Carotid), N(%)b

1400 (35.3)

782/2303 (34.0)

507/1292 (39.2)

111/372 (29.8)

Previous AMI, CABG, arrest, N(%)b

678 (17.1)

391/2303 (17.0)

226/1292 (17.5)

61/372 (16.4)

Previous CHF, N(%)b

401 (10.1)

237/2303 (10.3)

130/1292 (10.1)

34/372 (9.1)

Previous stroke, ICH, TIA, N(%)b

527 (13.3)

289/2303 (12.5)

207/1292 (16.0)

31/372 (8.3)

Previous peripheral arterial disease, N(%)b

364 (9.2)

196/2303 (8.5)

141/1292 (10.9)

27/372 (7.3)

Hypertension, N(%)b

1963 (49.5)

1126/2303 (48.9)

657/1292 (50.9)

180/372 (48.4)

Kidney disease, N(%)b

755 (19.0)

470/2303 (20.4)

230/1292 (17.8)

55/372 (14.8)

Proteinuria, N(%)b

521 (13.1)

344/2303 (14.9)

130/1292 (10.1)

47/372 (12.6)

Diabetes, N(%)b

833 (21.0)

504/2303 (21.9)

264/1292 (20.4)

65/372 (17.5)

Hyperlipidemia, N(%)a

1555 (43.4)

858/1945 (44.1)

588/1362 (43.2)

109/275 (39.6)

Body Mass Index (kg/m2), median(Q1-Q3)a

25.9 (23.1–29.4)

26.3 (23.5–29.6)

25.6 (22.9–29.1)

25.3 (22.6–28.7)

Heart rate (bpm), mean(SD)a

74.8 (14.6)

74.0 (14.1)

75.1 (14.7)

76.7 (15.8)

Systolic blood pressure (mmHg), mean(SD)a

141.7 (24.1)

140.7 (22.6)

145.1 (25.4)

134.6 (24.2)

Diastolic blood pressure (mmHg), mean(SD)a

80.0 (12.4)

80.8 (12.0)

80.3 (12.3)

75.4 (13.5)

Total Cholesterol (mmol/L), median(Q1-Q3)a

5.1 (4.2–6.0)

5.1 (4.3–6.0)

5.1 (4.2–6.0)

4.8 (3.9–5.8)

HDL-Cholesterol (mmol/L), median(Q1-Q3)a

1.3 (1.1–1.6)

1.3 (1.1–1.6)

1.3 (1.1–1.6)

1.2 (1.0–1.5)

Hb (mmol/L), mean(SD)a

8.6 (1.1)

8.8 (1.0)

8.5 (1.1)

8.1 (1.3)

Creatinine (μmol/L), median(Q1-Q3)a

76.0 (64.0–95.0)

76 (65.0–93.0)

75 (63.0–94.0)

79 (65.0–102.8)

eGFR (CKD epi), mean(SD)a

77.5 (25.9)

80.1 (24.9)

75.7 (25.5)

73.7 (28.6)

HbA1c (mmol/mol), median(Q1-Q3)a

38.0 (35.0–44.0)

38 (35.0–43.0)

38 (35.0–44.0)

41 (36.0–52.0)

10-yr risk on CVD, median(Q1-Q3)c

10.0 (3.0–28.0)

9.0 (3.0–24.6)

12.7 (4.0–29.9)

8.0 (5.0–18.5)

  1. Notes: a= routine care data from the EHR; b= data from the UCC-CVRM questionnaire; c= calculated based on routine care and questionnaire data; N number, Q1 first quartile, Q3 third quartile, % percentage, OPD Outpatient department, MET Metabolic Equivalent of Task, AMI Acute myocardial infarction, CABG Coronary artery bypass grafting, CHF Congestive heart failure, ICH Intracranial hemorrhage, TIA Transient ischemic attack, PAD Peripheral arterial disease, AAA Abdominal aortic aneurysm, bpm Beats per minute, SD Standard deviation, HDL High-density lipoprotein, Hb Haemoglobin, eGFR Estimated glomerular filtration rate using the CKD-EPI formula, CKD Chronic kidney disease, HbA1c glycated haemoglobin, yr year