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Table 2 Weighted kappa, sensitivity and specificity along with the 95% CI for identification of AHD treatment between RAAS-generated clusters and AHD classification via scanning drug boxes

From: Cluster analysis of angiotensin biomarkers to identify antihypertensive drug treatment in population studies

 

Weighted kappa

Sensitivity

Specificity

AHD group

Cluster1

Cluster2

Cluster3

Cluster1

Cluster2

Cluster3

Cluster1

Cluster2

Cluster3

Normotensive

63(58–68)

46(39–52)

12(4–19)

77(68–85)

23(15–32)

0(0–4)

48(44–51)

70(66–73)

83(80–85)

Hypertensive

64(59–69)

44(37–50)

14(6–21)

82(73–89)

18(11–27)

0(0–4)

48(45–52)

69(65–72)

83(80–85)

Non-AHD

60(56–66)

41(34–48)

18(10–25)

91(84–96)

9(4–16)

0(0–4)

50(46–53)

68(64–71)

83(80–85)

Beta blockers

45(39–52)

22(17–28)

6(1–12)

89(81–94)

11(6–19)

0(0–4)

49(46–53)

49(46–53)

0(0–4)

ACEi

12(4–20)

45(39–52)

82(78–85)

24(16–34)

21(14–31)

55(44–65)

40(36–44)

69(66–73)

90(88–93)

ACEi + diuretics

25(19–31)

22(17–28)

78(75–82)

22(14–31)

11(6–19)

67(57–76)

40(36–43)

68(64–71)

92(90–94)

ARB

23(18–29)

74(69–80)

45(39–49)

27(18–36)

73(64–82)

0(0–4)

40(37–44)

83(81–85)

83(80–85)

ARB + diuretics

21(15–27)

51(46–55)

44(38–51)

31(23–41)

69(59–77)

0(0–4)

41(37–45)

76(73–79)

83(80–85)

Non-RAAS*

23(16–31)

60(53–65)

16(8–24)

85(81–88)

15(12–19)

0(0–1)

74(69–78)

56(51–61)

70(65–74)

ACEi or ACEi + diur**

12(4–22)

45(38–54)

82(79–86)

23(17–30)

16(11–22)

61(54–68)

34(30–38)

66(62–70)

100(99–100)

ARB or ARB + diur***

70(64–74)

41(34–48)

27(19–34)

29(23–36)

71(64–77)

0(0–2)

36(32–40)

84(81–87)

80(76–83)

  1. * participants not on RAAS targeting drugs
  2. **group of participants who received the RAAS targeting ACEi or ACEi + diuretics
  3. ***Participants who received the RAAS targeting ARB or ARB + diuretics