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Table 4 Clinical predictors of angiotensin I, angiotensin II and aldosterone after accounting for cluster structure and AHD treatment

From: Cluster analysis of angiotensin biomarkers to identify antihypertensive drug treatment in population studies

Variables

Angiotensin I

Angiotensin II

Aldosterone

Est(SE)

P-value

Est(SE)

P-value

Est(SE)

P-value

Age, year

-0.025(0.005)

2.17 × 10− 6

-0.017(0.005)

0.0012

removed*

Sex M

0.416(0.087)

2.18 × 10− 6

0.308(0.077)

7.85 × 10− 5

-0.222(0.054)

4.95 × 10− 5

BMI kg/m2

0.018(0.01)

0.0666

0.014(0.009)

0.1353

0.016(0.006)

0.0113

HbA1c %

-0.109(0.101)

0.2839

removed*

removed*

Glucose mg/dl

removed*

0.001(0.003)

0.8870

0.003(0.002)

0.1492

Total cholesterol, mg/dl

0.002(0.001)

0.0743

removed*

removed*

eGFR ml/min/1.73m2

-0.013(0.004)

0.0002

-0.007(0.003)

0.0399

-0.006(0.002)

0.0013

Sodium, mmol/L

-0.034(0.018)

0.0627

-0.026(0.016)

0.1095

0.002(0.012)

0.8324

Potassium, mmol/L

0.135(0.113)

0.2356

0.119(0.102)

0.2417

-0.055(0.072)

0.4416

Cortisol, µg/dl

removed*

0.008(0.008)

0.3281

0.012(0.006)

0.0443

SBP, mmHg

removed*

-0.015(0.004)

2.69 × 10− 5

removed*

DBP, mmHg

-0.029(0.005)

3.70 × 10− 8

-0.007(0.007)

0.2694

0.001(0.003)

0.7244

DM

0.303(0.154)

0.0493

0.178(0.13)

0.1719

-0.074(0.092)

0.4215

  1. Est: estimate of the coefficient of association; SE: standard error of estimated coefficient
  2. *removed by the lasso penalization algorithm when a predictor is less influential