Characteristics, N (%) | Patients without OA a (N = 47) | Case Patientsa (N = 360) | Comparator Patientsa (N = 83) |
---|---|---|---|
Obesityb | 4 (8.5) | 101 (28.1) | 16 (19.3) |
Pain-related conditions | |||
Joint pain of hip | 2 (4.3) | 46 (12.8) | 5 (6.0) |
Joint pain of knee | 0 (0.0) | 83 (23.1) | 13 (15.7) |
Joint pain in other site(s) | 15 (31.9) | 148 (41.1) | 29 (34.9) |
Back pain | 0 (0.0) | 10 (2.8) | 2 (2.4) |
Unspecified pain | 12 (25.5) | 168 (46.7) | 19 (22.9) |
Other comorbidities | |||
Hypertension | 11 (23.4) | 153 (42.5) | 27 (32.5) |
Diabetes | 12 (25.5) | 47 (13.1) | 12 (14.5) |
Gastroesophageal reflux | 4 (8.5) | 90 (25.0) | 9 (10.8) |
Depression | 3 (6.4) | 56 (15.6) | 8 (9.6) |
Anxiety | 4 (8.5) | 47 (13.1) | 8 (9.6) |
Drug or alcohol abuse | 0 (0.0) | 16 (4.4) | 3 (3.6) |
Insomnia | 0 (0.0) | 14 (3.9) | 4 (4.8) |
Charlson Comorbidity Index category | |||
0 | 32 (68.1) | 230 (63.9) | 58 (69.9) |
1 | 9 (19.1) | 64 (17.8) | 14 (16.9) |
2 | 1 (2.1) | 26 (7.2) | 4 (4.8) |
≥ 3 | 5 (10.6) | 40 (11.1) | 7 (8.4) |
Medication use | |||
Any NSAIDs | 7 (14.9) | 148 (41.1) | 22 (26.5) |
Topical NSAIDs | 0 (0.0) | 37 (10.3) | 7 (8.4) |
COX-2 | 0 (0.0) | 37 (10.3) | 7 (8.4) |
Non-selective NSAIDs | 7 (14.9) | 117 (32.5) | 17 (20.5) |
Any opioids | 13 (27.7) | 178 (49.4) | 20 (24.1) |
Short-acting opioids | 7 (14.9) | 145 (40.3) | 15 (18.1) |
Long-acting opioids | 0 (0.0) | 4 (1.1) | 1 (1.2) |
Opioid mixed mechanismb | 7 (14.9) | 66 (18.3) | 7 (8.4) |
Oral corticosteroids | 0 (0.0) | 1 (0.3) | (0.0) |
H2 blockers | 3 (6.4) | 33 (9.2) | 9 (10.8) |
IA steroids injections | 10 (21.3) | 288 (80.0) | 21 (25.3) |
HA injections | 1 (2.1) | 89 (24.7) | 3 (3.6) |
OA related Surgeries | |||
Hip replacement | 0 (0.0) | 80 (22.2) | 2 (2.4) |
Knee replacement | 1 (2.1) | 134 (37.2) | 4 (4.8) |
Nerve Block Ablation | 7 (14.9) | 208 (57.8) | 14 (16.9) |