Algorithm | TP | FP | TN | FN | Sensitivity | Specificity | NPV | PPV | Accuracy |
---|---|---|---|---|---|---|---|---|---|
1. ≥ 1 code for any OA-related surgical procedures | 263 | 0 | 77 | 150 | 0.64 | 1.00 | 0.34 | 1.00 | 0.69 |
2. ≥ 2 medical encounters on different days resulting in diagnosis of a relevant psychiatric comorbidity (i.e., anxiety, depression), with at least two encounters for psychiatric comorbidities both occurring within 180 days of any OA diagnosis | 87 | 14 | 63 | 326 | 0.21 | 0.82 | 0.16 | 0.86 | 0.31 |
3. ≥ 2 medical encounters resulting in diagnosis of relevant psychiatric comorbidities, with at least two encounters for the psychiatric comorbidities within 90 days of any OA diagnosis | 83 | 12 | 65 | 330 | 0.20 | 0.84 | 0.16 | 0.87 | 0.30 |
4. ≥ 2 prescriptions for opioids within 90 days of any OA diagnosis | 66 | 5 | 72 | 347 | 0.16 | 0.94 | 0.17 | 0.93 | 0.28 |
5. ≥ 2 prescriptions for oral NSAIDs (including COX-2 inhibitors) within 90 days of any OA diagnosis | 1 | 0 | 77 | 412 | 0.00 | 1.00 | 0.16 | 1.00 | 0.16 |
6. ≥ 2 prescriptions for topical NSAIDs (including COX-2 inhibitors) within 90 days of any OA diagnosis | 10 | 2 | 75 | 403 | 0.02 | 0.97 | 0.16 | 0.83 | 0.17 |
7. ≥ 1 administration of HA or IA corticosteroids | 331 | 3 | 74 | 82 | 0.80 | 0.96 | 0.47 | 0.99 | 0.83 |
8. ≥ 2 administrations of HA or IA corticosteroids at least 90 days apart | 191 | 1 | 76 | 222 | 0.46 | 0.99 | 0.26 | 0.99 | 0.54 |
9. ≥ 1 administration of a nerve block ± 30 days of any OA diagnosis | 191 | 3 | 74 | 222 | 0.46 | 0.96 | 0.25 | 0.98 | 0.54 |
10. ≥ 1 claim for a mobility aid including walking cane, walker, and wheelchair, or crutch ± 30 days of any OA diagnosis | 79 | 5 | 72 | 334 | 0.19 | 0.94 | 0.18 | 0.94 | 0.31 |
11. ≥ 1 code for physical and/or occupational therapy ± 30 days of any OA diagnosis | 175 | 12 | 65 | 238 | 0.42 | 0.84 | 0.21 | 0.94 | 0.49 |
12. OA-related costs > 30% mean OA-related costs for the cohort | 147 | 0 | 77 | 266 | 0.36 | 1.00 | 0.22 | 1.00 | 0.46 |
13. OA-related costs > 50% mean OA-related costs for the cohort | 0 | 0 | 77 | 413 | 0.00 | 1.00 | 0.16 | N/A | 0.16 |
14. ≥ 2 codes for X-ray examinations in a 1-year period | 295 | 10 | 67 | 118 | 0.71 | 0.87 | 0.36 | 0.97 | 0.74 |
Combined algorithm (using OR function) | |||||||||
Combinations of all algorithms with performance ≥ 0.98 PPV | 360 | 6 | 71 | 53 | 0.87 | 0.92 | 0.57 | 0.98 | 0.88 |
Combinations of all algorithms with performance ≥ 0.95 PPV | 372 | 13 | 64 | 41 | 0.90 | 0.83 | 0.61 | 0.97 | 0.89 |
Combinations of all algorithms with performance ≥ 0.90 PPV | 378 | 21 | 56 | 35 | 0.92 | 0.73 | 0.62 | 0.95 | 0.89 |
Combinations of all algorithms with performance ≥ 0.85 PPV | 378 | 25 | 52 | 35 | 0.92 | 0.68 | 0.60 | 0.94 | 0.88 |
Combinations of all algorithms with performance ≥ 0.80 PPV | 378 | 26 | 51 | 35 | 0.92 | 0.66 | 0.59 | 0.94 | 0.88 |