Table 1 Features included in the random forest. Level 1 domains are in bold. Level 2 domains are indented below Level 1 domains. Level 3 features are italicized, with brackets indicating the number of features if > 1

Demographic Characteristics

10

 Age

1

 Sex

1

 Race

3

 Other Demographic (Education, Marital Status [4])

5

Measured Medical Risk Factors

28

 Anthropometry (Body Mass Index, Height, Hip, Neck, Waist, Weight)

6

 Electrocardiogram

15

 Blood Pressure (Systolic, Diastolic)

2

 Lung Function (Forced Expiratory Volume, Forced Vital Capacity)

2

 Lipids (HDL, Triglycerides, Total Cholesterol)

3

Polysomnography

15

 Continuity (Efficiency, Sleep–Wake Shifts, Wake after Sleep Onset)

3

 Duration (Sleep Duration, Time in Bed)

2

 REM Sleep (Percent REM, REM Latency)

2

 Sleep Disordered Breathing (Apnea–Hypopnea Index, Avg SaO₂, Min SaO₂, T90)

4

 Sleep Staging (3/4–1/2 shifts, % Stage 1, % Stage 2, % Stage 3–4)

4

Health Behaviors

4

 Smoking (Smoking Status [2], Pack-Years of Smoking)

3

 Alcohol Use

1

Self-Report Sleep

30

 Sleep Apnea Symptoms and Diagnoses (Ever Snored, Sleep Apnea Diagnoses [2], Stop

Breathing)

4

 Sleep Health and Disturbances (Sleep Continuity, Sleepiness [3], Duration [2], Timing [4],

Insomnia [6], Sleep Disturbances [10])

26

Self-Reported Medical Risk Factors

27

 Cardiovascular Disease (Angina, Coronary Angioplasty, Coronary Artery Bypass Graft, Heart

Failure, Hypertension, Myocardial Infarction, Pacemaker, Other Heart Surgery)

8

 Diabetes

1

 SF-36 Emotional (Mental Component Total; Mental Health, Role Limitations, Social Functioning

Subscales)

4

 SF-36 Physical (Physical Component Total; Body Pain, General Health, Physical Functioning,

Role Limitations, Vitality Subscales)

6

 Pulmonary Measures (Asthma [2], Chronic Bronchitis, Chronic Obstructive Pulmonary Disorder,

Coughing, Emphysema, Oxygen Therapy, Phlegm)

8

Medication Use

43

 Cardiovascular Medications (Ace Inhibitors [2], Alpha-Blockers, Anti-Arrhythmics [4],

Anticoagulants, Beta-Blockers, Calcium Channel Blockers [3], Digitalis, Diuretics [4],

Nitrates, Nitroglycerine, Phosphodiosterase Inhibitors, Sympathomimetics, Vasodilators [4],

Anti-hypertensive Medication)

26

 Cholesterol Medications

2

 Diabetes Medications

2

 Other Medications (Aspirin [2], Estrogen/Progesterone [3], Gastrointestinal, Non-Steroidal Anti-

Inflammatory Drugs, Psychiatric [3], Pulmonary [2], Thyroid)

13