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Fig. 1 | BMC Medical Research Methodology

Fig. 1

From: Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity

Fig. 1

Simulation showing the probability of rejection of the null hypothesis (i.e., of detecting heterogeneity) using Cochran’s Q, Adjusted Q, and the IPD method. For Cochran’s Q and Adjusted Q, two rwCC are separately compared to a SAT and the resulting statistics are assessed for heterogeneity. For the IPD method, the two rwCC are directly compared. 1000 replicates were run for each scenario. For the Adjusted Q test, 1000 bootstrap samples were generated for each replicate. There are 100 subjects in the SAT and in each rwCC

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