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Table 2 Operating characteristics of a two-step procedure for deciding whether or not to pool

From: Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity

 

Type I error

Response difference (%)

SAT response (%)

rwCC #1 response (%)

rwCC #2 response (%)

Pooling probabilitya

Conditional on pooling

If always pool

Expected when always pooling

Average when pooling

50

50

50

0.94 (0.0008)

0.04 (0.001)

0.04 (0.0008)

0

0.01 (0.0003)

50

50

40

0.87 (0.001)

0.06 (0.001)

0.06 (0.001)

5

5.01 (0.0003)

50

50

30

0.67 (0.001)

0.14 (0.001)

0.13 (0.001)

10

10.35 (0.0004)

50

50

20

0.36 (0.002)

0.3 (0.002)

0.27 (0.002)

15

16.04 (0.0005)

  1. aData is pooled when heterogeneity is not detected