Table 2 Participant characteristics of ADNI dataset at baseline stratified by cognitive status. Numeric variables are indicated with * and are given with median and 25–75% interquartile range (IQR). All other variables are categorical variables with two categories, and the absolute number and the column-wise percentage of the reference category are given. Absolute numbers of missing values (Nmiss) are given. Abbreviations: Body Mass Index (BMI), Cerebrospinal fluid (CSF), Amyloid β (Aβ), Mini Mental State Exam score (MMSE)
Variables | Cognitive normal n = 523 (30.1%) | Cognitive impairment n = 1214 (69.9%) | Total n = 1737 (100%) |
|---|---|---|---|
Age* | 73.7 (70.5, 78.0) | 74.0 (68.3, 79.3) | 73.9 (69.2, 78.9) |
APOE ε4 | 149 (28.6%) Nmiss: 2 | 660 (54.8%) Nmiss: 10 | 809 (46.9%) Nmiss:12 |
sex (male) | 253 (48.4%) | 704 (58.0%) | 957 (55.1%) |
education* (years) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) |
CSF-Aβ* (pg/ml) | 1271 (820.8, 1734.0) Nmiss: 156 | 741.5 (559.1, 1130.3) Nmiss: 366 | 854.2 (596.2, 1395.5) Nmiss: 522 |
CSF-tau* (pg/ml) | 214.3 (175.2, 287.8) Nmiss: 156 | 281.6 (210.4, 379.2) Nmiss: 366 | 257.8 (193.4, 349.7) Nmiss: 522 |
history of alcohol abuse | 16 (3.1%) Nmiss: 6 | 27 (2.3%) Nmiss: 27 | 43 (2.5%) Nmiss: 33 |
history of smoking | 115 (26.8%) Nmiss: 94 | 223 (23.2%) Nmiss: 254 | 338 (24.3%) Nmiss: 348 |
BMI* | 28.6 (25.8, 32.5) Nmiss: 4 | 28.17 (25.5, 31.2) Nmiss: 5 | 28.31 (25.5, 31.6) Nmiss: 9 |
history of hypertension | 130 (24.9%) | 460 (38.0%) Nmiss: 5 | 590 (34.1%) Nmiss: 5 |
history of cardiovascular events | 343 (65.6%) | 835 (68.8%) | 1178 (67.8%) |
MMSE* | 29.0 (29.0, 30.0) | 27.0 (25.0, 29.0) | 28.0 (25.0, 29.0) |