Table 1 Descriptive characteristics of the analysis sample at inclusion and over follow-up, MEMENTO cohort, France, 2011-2019 (N=2186)
Inclusion in the study | Follow-up | ||||
|---|---|---|---|---|---|
Variable | Mean/n | SD/% | N | Repeated measures | N\(^*\) |
Individuals characteristics | |||||
Age (years) | 70.9 | 8.7 | 2186 | ||
Female | 1349 | 61.7% | 2186 | ||
>12 years education | 856 | 39.2% | 2186 | ||
APOE4 carrier | 654 | 29.9% | 2186 | ||
CDR sum of the boxes | |||||
= 0 | 784 | 35.9% | 2186 | ||
= 0.5 | 794 | 36.3% | 2186 | ||
= 1 | 323 | 14.8% | 2186 | ||
> 1 | 285 | 13.0% | 2186 | ||
Markers of AD (CSF) | |||||
t-tau (pg/ml) | 376.0 | 264.8 | 341 | 1.3 | 395 |
p-tau (pg/ml) | 62.6 | 29.5 | 342 | 1.3 | 396 |
A\(\beta _{42}\) (pg/ml) | 1096.2 | 411.2 | 342 | 1.3 | 396 |
Brain imaging markers | |||||
WMH volume (mm3) | 9.9 | 13.2 | 1993 | 1.7 | 2056 |
Hippocampal volume (cm3) | 6.5 | 1.3 | 2047 | 1.7 | 2048 |
Entorhinal cortex (mm) | 3.3 | 0.4 | 2041 | 1.7 | 2057 |
Middle temporal cortex (mm) | 2.7 | 0.1 | 2047 | 1.7 | 2064 |
Fusiform cortex (mm) | 2.6 | 0.1 | 2047 | 1.7 | 2064 |
PET-FDG (SUVr) | 2.1 | 0.3 | 1236 | 1.5 | 1400 |
Cognitive tests | |||||
Verbal Fluency (animals cited) | 28.3 | 8.8 | 2147 | 4.6 | 2164 |
TMT-A (good moves/sec) | 0.6 | 0.2 | 2165 | 4.6 | 2184 |
Free recalls FCSRT (sum score) | 26.1 | 8.3 | 2169 | 4.5 | 2176 |