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Table 1 Severity grading scale for symptom reporting

From: The heterogeneity of symptom reporting across study sites: a secondary analysis of a randomised placebo-controlled multicentre antimalarial trial

Systemic (General)

Mild (Grade 1)

Moderate (Grade 2)

Severe (Grade 3)

Potentially life threatening (Grade 4)

Nausea/

vomiting

No interference

with activity or 1 – 2 episodes/24 h

Some interference

with activity or > 2

episodes/24 h

Prevents daily activity, requires

outpatient IV hydration

Emergency department visit or

hospitalisation for

hypotensive shock

Diarrhoea

2 – 3 loose stools or < 400 g/24 h

4 – 5 stools or

400 – 800 g/24

hours

6 or more watery stools or > 800 g/24 h or requires outpatient IV hydration

Emergency department visit or

hospitalisation

Other illness e.g. anorexia, abdominal pain, dizziness

No interference with activity

Some interference

with activity not

requiring medical

intervention

Prevents daily

activity and

requires medical

intervention

Emergency department visit or

hospitalisation