A systematic review of randomised controlled trials with adaptive and traditional group sequential designs – applications in cardiovascular clinical trials

Table 1 Search strategy of key words used in the study

Search strategy
Group	keywords
Clinical trials - phase II-III	Phase IIb-IIIb, 2b-3b, 2b/3b, IIb/IIIb, 2b-3, 2b/3, IIb/III, 2–3, II-III.
Randomised controlled trials	randomiz* or randomis* or trial*
Adaptive designs/traditional group sequential design	adapt, design or rule
	seamless
	group sequential
	sample size re-estimation, re-estimations, sample size adjustment or sample size modification
	MAMS or multi-arm multi-stage or multi* arm or multi* stage or drop the loser or pick the winner or play the winner or two-stage adaptive
	treatment switching or treatment adaptive
	adaptive dose*.
	treatment switching or treatment adaptive
	adaptive hypothesis
	biomarker adaptive or biomarker adaptive design or biomarker or enrichment
	multiple adaptive
	interim monitoring or interim monitor or Bayesian adaptive or stopping rule* or stopping boundar*, interim
	adaptive clinical trial* or adaptive design or flexible design or adaptive method
Cardiovascular Diseases	Cardiovascular Diseases, Cardiovascular disease

ISSN: 1471-2288