Table 1 Example TrialProbe entries. The 10 entries of our reference set with the largest denoised odds ratio. Each entry corresponds to a drug vs. drug (columns 2 and 3) comparison with respect to an adverse event (column 1). We also report the NCT of the clinical trial(s) that furnish the experimental evidence for the comparison (column 4), the summarized data from the RCT in the form of a contingency table as in (1) (column 5) and the denoised odds ratio \(\textrm{exp}(\widehat{\omega }_i^{\text {EB}})\) (5) (column 6)
From: Using public clinical trial reports to probe non-experimental causal inference methods
Adverse Event (ICD10) | Drug A (ATC) | Drug B (ATC) | Clinical Trial NCTs | Contingency Table | Denoised Odds Ratio |
|---|---|---|---|---|---|
Hiccups (R06.6) | Nicotine (N07BA01) | Bupropion (N06AX12) | 332644 | \(\left[ \begin{array}{rr} 0 &{} 264 \\ 35 &{} 225 \\ \end{array}\right]\) | 58.63 |
Dry Mouth (K11.7) | Bupropion (N06AX12) | Nicotine (N07BA01) | 332644 | \(\left[ \begin{array}{rr} 0 &{} 260 \\ 20 &{} 244 \\ \end{array}\right]\) | 27.30 |
Conjunctivitis (H10) | Brimonidine (D11AX21) | Brinzolamide (S01EC04) | 1297920 | \(\left[ \begin{array}{rr} 0 &{} 234 \\ 15 &{} 220 \\ \end{array}\right]\) | 15.56 |
Nausea (R11.0) | Dulaglutide (A10BJ05) | Glimepiride (A10BB12) | 1644500 | \(\left[ \begin{array}{rr} 1 &{} 242 \\ 25 &{} 219 \\ \end{array}\right]\) | 12.82 |
Dysgeusia (R43.2) | Brinzolamide (S01EC04) | Brimonidine (D11AX21) | 1297920 1297517 | \(\left[ \begin{array}{rr} 2 &{} 453 \\ 38 &{} 422 \\ \end{array}\right]\) | 11.02 |
Heartburn (R12) | Nicotine (N07BA01) | Bupropion (N06AX12) | 332644 | \(\left[ \begin{array}{rr} 2 &{} 262 \\ 31 &{} 229 \\ \end{array}\right]\) | 8.52 |
Vomiting (R11.1) | Dulaglutide (A10BJ05) | Glimepiride (A10BB12) | 1644500 | \(\left[ \begin{array}{rr} 1 &{} 242 \\ 19 &{} 225 \\ \end{array}\right]\) | 7.60 |
Hypoglycaemia (E16.2) | Glipizide (A10BB07) | Sitagliptin (A10BH01) | 86515 94770 509262 | \(\left[ \begin{array}{rr} 61 &{} 1201 \\ 279 &{} 754 \\ \end{array}\right]\) | 7.10 |
Dysgeusia (R43.2) | Telavancin (J01XA03) | Vancomycin (A07AA09) | 107978 91819 | \(\left[ \begin{array}{rr} 62 &{} 876 \\ 311 &{} 618 \\ \end{array}\right]\) | 7.06 |
Nausea (R11.0) | Tigecycline (J01AA12) | Ertapenem (J01DH03) | 366249 | \(\left[ \begin{array}{rr}46 &{} 462 \\ 233 &{} 320 \\ \end{array}\right]\) | 6.97 |