Comparing analytical strategies for balancing site-level characteristics in stepped-wedge cluster randomized trials: a simulation study

Ma, Clement; Lee, Alina; Courtney, Darren; Castle, David; Wang, Wei

doi:10.1186/s12874-023-02027-y

Table 3 Relative mean bias of the estimated treatment effects

From: Comparing analytical strategies for balancing site-level characteristics in stepped-wedge cluster randomized trials: a simulation study

ICC	Number of sites	Sample size at each step	Imbalance index	Percentiles	With learning effect			With constant effect
					Effect size			Effect size
					0.2	0.5	1.0	0.2	0.5	1.0
0.01	6	10	0.000	0^th	0.016	0.007	0.004	0.005	0.003	0.001
			0.239	33^rd	0.011	0.004	0.001	0.004	0.001	0.001
			0.478	67^th	0.013	0.003	0.005	0.001	0.001	0.001
			0.717	83^rd	0.013	0.005	0.004	0.001	0.001	0.001
			0.956	100^th	0.015	0.007	0.000	0.011	0.005	0.001
		20	0.000	0^th	0.004	0.000	0.005	0.000	0.003	0.001
			0.239	33^rd	0.001	0.004	0.002	0.002	0.003	0.000
			0.478	67^th	0.001	0.006	0.009	0.000	0.002	0.002
			0.717	83^rd	0.011	0.009	0.009	0.005	0.001	0.002
			0.956	100^th	0.007	0.008	0.002	0.006	0.002	0.000
	12	10	0.000	0^th	0.007	0.002	0.001	0.002	0.002	0.000
			0.148	33^rd	0.001	0.000	0.001	0.003	0.000	0.001
			0.296	67^th	0.006	0.008	0.003	0.001	0.001	0.001
			0.414	83^rd	0.012	0.015	0.004	0.004	0.001	0.001
			0.946	100^th	0.002	0.005	0.004	0.004	0.001	0.000
		20	0.000	0^th	0.005	0.003	0.002	0.002	0.001	0.001
			0.148	33^rd	0.011	0.002	0.002	0.001	0.002	0.001
			0.296	67^th	0.001	0.003	0.002	0.000	0.001	0.000
			0.414	83^rd	0.012	0.000	0.002	0.002	0.002	0.001
			0.946	100^th	0.018	0.006	0.002	0.006	0.001	0.000
0.10	6	10	0.000	0^th	0.010	0.010	0.001	0.007	0.003	0.000
			0.239	33^rd	0.012	0.001	0.001	0.008	0.000	0.002
			0.478	67^th	0.039	0.003	0.006	0.009	0.001	0.001
			0.717	83^rd	0.019	0.007	0.001	0.004	0.002	0.001
			0.956	100^th	0.035	0.012	0.001	0.016	0.005	0.001
		20	0.000	0^th	0.017	0.006	0.002	0.002	0.004	0.001
			0.239	33^rd	0.008	0.003	0.004	0.004	0.002	0.000
			0.478	67^th	0.002	0.008	0.010	0.002	0.002	0.002
			0.717	83^rd	0.003	0.001	0.012	0.007	0.002	0.002
			0.956	100^th	0.007	0.003	0.003	0.007	0.001	0.000
	12	10	0.000	0^th	0.010	0.007	0.002	0.003	0.002	0.000
			0.148	33^rd	0.000	0.004	0.001	0.004	0.000	0.001
			0.296	67^th	0.005	0.011	0.003	0.001	0.001	0.001
			0.414	83^rd	0.008	0.014	0.001	0.001	0.002	0.001
			0.946	100^th	0.002	0.007	0.005	0.004	0.001	0.000
		20	0.000	0^th	0.006	0.004	0.001	0.002	0.001	0.001
			0.148	33^rd	0.016	0.002	0.002	0.001	0.001	0.001
			0.296	67^th	0.000	0.005	0.002	0.002	0.001	0.001
			0.414	83^rd	0.012	0.001	0.001	0.002	0.002	0.001
			0.946	100^th	0.016	0.005	0.002	0.005	0.001	0.000

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ISSN: 1471-2288

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