Fig. 2
From: Adaptive designs in critical care trials: a simulation study
Retrospective analysis using group-sequential designs. Panels A, B, C and D show the critical values, represented as dots (red: no boundary crossing, black: boundary crossing, blue: final stage) at each interim or final analysis with stopping boundaries of all group-sequential designs (red: Haybittle-Peto, brown: Hwang-Shih-DeCani, green: O’Brien-Fleming) across different numbers of interim analyses conducted for the ADRENAL trial, respectively. Panels E, F, G and H also show the same information for the NICE-SUGAR trial