Table 1 Comparison of the performance of different estimation methods of the effect of cumulative exposure to psychosocial stressors at work on blood pressure in the parametric plasmode simulation scenario
| Â | Intermittent | Cessation | Onset | Chronic |
|---|---|---|---|---|
Bias | ||||
    IPTW | -0.37 | -0.03 | 0.23 | -0.05 |
    g-computation | 0.27 | 0.02 | 0.16 | -0.01 |
    TMLE | 0.26 | -0.09 | 0.24 | -0.07 |
    TMLE+SL | 0.25 | -0.09 | 0.24 | -0.07 |
    Baseline adjustment | -0.40 | -0.11 | 0.48 | 0.01 |
    Baseline and Time-varying covariate adjustment | -0.44 | -0.08 | 0.21 | -0.19 |
Standard deviation | ||||
    IPTW | 1.29 | 1.05 | 1.27 | 1.29 |
    g-computation | 0.53 | 0.84 | 0.86 | 1.05 |
    TMLE | 1.20 | 1.00 | 1.05 | 1.18 |
    TMLE+SL | 1.20 | 1.00 | 1.05 | 1.18 |
    Baseline adjustment | 1.12 | 0.98 | 1.06 | 1.17 |
    Baseline and Time-varying covariate adjustment | 1.11 | 0.98 | 1.06 | 1.19 |
RMSE | ||||
    IPTW | 1.35 | 1.05 | 1.29 | 1.29 |
    g-computation | 0.59 | 0.84 | 0.88 | 1.05 |
    TMLE | 1.22 | 1.00 | 1.08 | 1.18 |
    TMLE+SL | 1.22 | 1.00 | 1.08 | 1.18 |
    Baseline adjustment | 1.19 | 0.98 | 1.16 | 1.17 |
    Baseline and Time-varying covariate adjustment | 1.20 | 0.98 | 1.08 | 1.21 |
Coverage of the 95% confidence interval | ||||
    IPTW | 93% | 96% | 95% | 95% |
    g-computation | 90% | 94% | 94% | 94% |
    TMLE | 92% | 94% | 93% | 93% |
    TMLE+SL | 92% | 94% | 93% | 93% |
    Baseline adjustment | 92% | 95% | 92% | 95% |
    Baseline and Time-varying covariate adjustment | 92% | 95% | 94% | 94% |