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Fig. 2 | BMC Medical Research Methodology

Fig. 2

From: Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva

Fig. 2

Key challenges and protocol amendments during the PVO-1A-001, PVO-1A-201, and PVO-1A-202 studies. CAJIS: Cumulative Analogue Joint Involvement Scale; CT: computed tomography; DMC: data monitoring committee; DXA: dual-energy X-ray absorptiometry; FOP: fibrodysplasia ossificans progressiva; FOP-PFQ: FOP Physical Function Questionnaire; HO: heterotopic ossification; IFOPA: International FOP Association; NHS: natural history study; OLE: open-label extension; PVO: palovarotene; RCT: randomized controlled trial; ROM: range of motion; WBCT: whole-body computed tomography

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BMC Medical Research Methodology

ISSN: 1471-2288

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