Sample size allocation in different trial setting | Simulation | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(1) | (2) | (3) | Power (%) | Power Difference (%) | |||||||||
Risk of Z | N | Z | A | Z | A | B | Z | B | (1) | (2) | (3) | (2) - (1) | (3) - (1) |
0.35 | 80 | 35 | 45 | 39 | 10 | 31 | 41 | 39 | 42.6 | 50.7 | 55.5 | 8.1 | 12.9 |
0.40 | 80 | 35 | 45 | 38 | 10 | 32 | 40 | 40 | 60.7 | 69.5 | 73.3 | 8.8 | 12.6 |
0.45 | 80 | 34 | 46 | 38 | 10 | 32 | 40 | 40 | 76.5 | 83.6 | 86.7 | 7.1 | 10.2 |
0.50 | 80 | 34 | 46 | 38 | 10 | 32 | 40 | 40 | 87.7 | 92.6 | 94.4 | 4.9 | 6.6 |
0.35 | 100 | 44 | 56 | 49 | 10 | 41 | 51 | 49 | 52.2 | 60.5 | 64.0 | 8.2 | 11.8 |
0.40 | 100 | 43 | 57 | 48 | 10 | 42 | 50 | 50 | 71.2 | 79.4 | 81.6 | 8.2 | 10.4 |
0.45 | 100 | 43 | 57 | 48 | 10 | 42 | 50 | 50 | 85.6 | 91.1 | 92.6 | 5.5 | 7.1 |
0.50 | 100 | 43 | 57 | 48 | 10 | 42 | 50 | 50 | 94.2 | 96.9 | 97.5 | 2.7 | 3.3 |
0.35 | 120 | 53 | 67 | 59 | 10 | 51 | 61 | 59 | 60.3 | 69.1 | 71.9 | 8.9 | 11.6 |
0.40 | 120 | 52 | 68 | 58 | 10 | 52 | 60 | 60 | 79.6 | 86.1 | 87.9 | 6.5 | 8.3 |
0.45 | 120 | 51 | 69 | 58 | 10 | 52 | 60 | 60 | 91.6 | 95.2 | 96.0 | 3.7 | 4.4 |
0.50 | 120 | 51 | 69 | 58 | 10 | 52 | 60 | 60 | 97.3 | 98.6 | 98.8 | 1.3 | 1.6 |