Selecting a randomization method for a multi-center clinical trial with stochastic recruitment considerations

Table 3 Simulated average proportion of centers (among all centers that recruited at least 2 patients) that resulted in the allocation ratio more skewed that 1:2 or 2:1 under Scenarios 1–4

Randomization design	Scenario 1	Scenario 2	Scenario 3	Scenario 4
U-PBD \((b)\)	0.347	0.322	0.382	0.323
U-BUD \((b)\)	0.347	0.323	0.382	0.323
U-EUD \((b)\)	0.347	0.323	0.383	0.323
U-BSD \((b)\)	0.347	0.322	0.381	0.324
R-PBD \((b)\)	0.334	0.308	0.370	0.308
R-BUD \((b)\)	0.333	0.308	0.371	0.308
R-EUD \((b)\)	0.334	0.308	0.371	0.307
R-BSD \((b)\)	0.335	0.308	0.371	0.310
C-PBD \((b)\)	0.015	0.045	0.083	0.139
C-BUD \((b)\)	0.057	0.080	0.130	0.167
C-EUD \((b)\)	0.043	0.060	0.097	0.129
C-BSD \((b)\)	0.085	0.119	0.195	0.265
DBR (\(b, b, b\))	0.083	0.116	0.191	0.255
DBR (\(b,2b,2b\))	0.083	0.117	0.191	0.259
DBR (\(b,2b,4b\))	0.084	0.117	0.192	0.259
CRD	0.349	0.326	0.385	0.328

ISSN: 1471-2288