Table 4 Numbers of participants providing outcome data at 3, 6 and 12 months, information (\(\text {I}=1/\text {var}(\beta _{s})\)) and test statistic (\(Z=\beta _{s}/\text {sd}(\beta _{s})\)) boundaries for putative START:REACTS trial designs where the sample size is \(N=188\) for [a] an expected fixed rate and [b] a decreasing rate of recruitment
[a] Fixed rate | [b] Decreasing rate | ||||||
|---|---|---|---|---|---|---|---|
Outcome | Â | Interim | End | Interim | End | ||
| Â | Â | 1 | 2 | Â | 1 | 2 | Â |
12 months | \(N_{3}\) | 47.0 | 65.8 | 188 | 47.0 | 65.8 | 188 |
6 months | \(N_{2}\) | 94.0 | 112.8 | 188 | 113.5 | 127.0 | 188 |
3 months | \(N_{1}\) | 117.5 | 136.3 | 188 | 138.9 | 149.8 | 188 |
Information | I | 0.101 | 0.137 | 0.326 | 0.104 | 0.139 | 0.326 |
Information fraction | \(\tau\) | 0.309 | 0.419 | 1.000 | 0.318 | 0.427 | 1.000 |
Boundary | lower | -0.706 | 0.581 | 1.907 | -0.706 | 0.581 | 1.910 |
| Â | upper | \(\infty\) | 3.090 | 1.907 | \(\infty\) | 3.090 | 1.910 |