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Table 1 Summary of comparing different methods on determining optimal cut-off in population based and simulation studies

From: Methods of determining optimal cut-point of diagnostic biomarkers with application of clinical data in ROC analysis: an update review

Author

Year of publication

Underlying distribution

Sample size

Performance

D

ND

Hajian-Tilak [15]

2018

Normal

Logistic

DOR had a poor performance in cut-point selection

Unal [5]

2017

Normal

Gamma

50

100

200

50

100

200

IU had the least MSE and relative bias compared with other methods

50

50

50

100

150

200

Habibzade et al. [11]

2016

Considering the costs of FP and FN, the analytical methods had a better performance than others

Perkins et al. [26]

2006

120

120

The difference between the Youden and Euclidean was negligible in determining optimal cut-point

Liu [7]

2012

Normal

50

100

150

50

100

150

Youden index had a higher MSE than Euclidean and product methods

100

200

200

200

100

200

Gerke et al. [27]

2022

Normal

Rota et al. [9]

2014

Normal

Gamma

50

100

200

50

100

200

Eucliden and product methods had lower MSE and relative bias than Youden index

50

50

50

100

150

200

  1. D Diseased, ND Nondiseased, DOR Diagnostic Odds Ratio, IU Index of Union, MSE Mean Square Errors, FP False Positive, FN False Negative