Skip to main content

Table 3 Result of cut-point selection with different methods by CRP and their diagnostic properties

From: Methods of determining optimal cut-point of diagnostic biomarkers with application of clinical data in ROC analysis: an update review

Methods

Cut-point (mg/L)

Se

(95%CI)

Sp

(95%CI)

PPV

(95%CI)

NPV

(95%CI)

LR + 

(95%CI)

LR-

(95%CI)

DOR

(95%CI)

Youden

7

0.67

(0.47,0.82)

0.83

(0.65,0.94)

0.80

(0.59,0.93)

0.71

(0.53,0.85)

4

(1.17,13.58)

0.40

(0.12,1.36)

10

(2.94,33.95)

Euclidian

7

0.67

(0.47,0.82)

0.83

(0.65,0.94)

0.80

(0.59,0.93)

0.71

(0.53,0.85)

4

(1.17,13.58)

0.40

(0.12,1.36)

10

(2.94,33.95)

Product

7

0.67

(0.47,0.82)

0.83

(0.65,0.94)

0.80

(0.59,0.93)

0.71

(0.53,0.85)

4

(1.17,13.58)

0.40

(0.12,1.36)

10

(2.94,33.95)

DOR

10

0.50

(0.31, 0.68)

0.97

(0.82, 0.99)

0.94

(0.69, 0.99)

0.66

(0.50, 0.79)

15

(1.81,124.59)

0.52

(0.06,4.30)

29

(3.49,240.81)

IU

6

0.77

(0.57,0.90)

0.70

(0.51,0.85)

0.72

(0.53,0.86)

0.75

(0.55,0.89)

2.56

(0.77,8.55)

0.33

(0.90,1.09)

7.67

(2.95,32.82)